GroupPeriodontitis...1 GroupPeriodontitis...2 GroupPeriodontitis...3 GroupPeriodontitis...4 GroupPeriodontitis...5 GroupPeriodontitis...6 1 Coefficients Standard Errors Test Statistics W p Values Adjusted p Values Differential Abundance Neisseria elongata (SP1) 0.288972931547762 0.780534613213853 0.370224365012995 0 0 TRUE Prevotella sp._HMT_317 (SP10) 0.818614192540542 1.40683391490827 0.581884033264805 0.560644796006223 1 FALSE Fusobacterium hwasookii (SP101) 0.438627271302362 0.86788259892926 0.505399315349234 0 0 TRUE Selenomonas dianae (SP104) 0.477371808903332 0.877976600141386 0.543718145593467 0 0 TRUE Fretibacterium sp._HMT_360 (SP105) 1.40367025618448 1.14069638409751 1.23053800796873 0 0 TRUE Leptothrix sp._HMT_025 (SP106) -4.8651384218528 1.5223018925859 -3.19590906741139 0 0 TRUE Dialister invisus (SP107) 0.256389104215877 1.18698658522805 0.216000001522021 0.828987746378492 1 FALSE Haemophilus parainfluenzae (SP109) -2.80384584391994 1.41816816031521 -1.97708982783588 0.0480314773880364 1 FALSE Tannerella forsythia (SP11) 2.28131490042926 0.843530075679994 2.70448554971821 0 0 TRUE Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saphenum (SP112) 1.27594338641443 0.867328737138359 1.47111854107849 0 0 TRUE Capnocytophaga sp._HMT_338 (SP114) -0.0224647044521905 0.90897719478463 -0.0247142662996218 0.980282875695079 1 FALSE Capnocytophaga sputigena (SP115) -0.697951506021641 0.944533715159156 -0.738937631150662 0.459944870309235 1 FALSE Porphyromonas endodontalis (SP116) 0.637965866680571 1.24132518530735 0.513939356287701 0.607294390405105 1 FALSE Prevotella enoeca (SP117) -1.3978458367475 1.01915763232732 -1.37156980667987 0.17019739850772 1 FALSE Lautropia mirabilis (SP14) -1.4266220277435 1.50664819358829 -0.946884636914343 0.343697567254097 1 FALSE Treponema lecithinolyticum (SP140) -0.41799219601831 0.912303019629458 -0.458172544674994 0.646828483203389 1 FALSE Treponema sp._HMT_237 (SP141) 1.94824932868798 1.08304548407479 1.79886196594255 0.0720405183008042 1 FALSE Bacteroidetes_[G-6] bacterium_HMT_516 (SP142) 0.129275517209941 0.640135534690428 0.20195022804422 0 0 TRUE Treponema denticola (SP143) 2.45092003771698 1.03420526753353 2.36985839722337 0.0177948990761445 1 FALSE Porphyromonas gingivalis (SP15) 3.13291824577924 1.0119762537911 3.09584166035773 0 0 TRUE Treponema maltophilum (SP150) 0.600469664284835 0.73738418275028 0.814324036684941 0 0 TRUE Streptococcus sanguinis (SP151) -0.887998586533491 0.950981835844304 -0.933770291989968 0.350422397015658 1 FALSE Prevotella maculosa (SP153) 0.805279314815738 0.863189587135524 0.932911294131849 0 0 TRUE Selenomonas noxia (SP154) 0.431126137030195 0.844945077780042 0.510241610215554 0 0 TRUE Alloprevotella tannerae (SP157) 1.00543232900177 0.925707737855145 1.08612285269576 0 0 TRUE Treponema sp._HMT_270 (SP158) -0.976820544026203 0.649933982358711 -1.50295348533888 0.132851039194276 1 FALSE Prevotella oralis (SP159) -1.43522813390692 1.1617154515458 -1.23543861966989 0.216667307155629 1 FALSE Peptidiphaga sp._HMT_183 (SP160) -0.515117286830968 1.09340160477444 -0.47111444192295 0.637559012460204 1 FALSE Leptotrichia sp._Oral_Taxon_B57 (SP161) 0.678327754147287 0.77450846601001 0.875817094216915 0 0 TRUE Centipeda sp._Oral_Taxon_B01 (SP163) 0.562323048116253 0.735292863977146 0.764760649348191 0 0 TRUE Campylobacter concisus (SP164) 0.41608415484173 0.777618148466287 0.535075159527052 0 0 TRUE Saccharibacteria_(TM7)_[G-5] bacterium_HMT_356 (SP165) -0.567756784404429 0.80759916941714 -0.703018039028185 0.482044507714886 1 FALSE Fretibacterium sp._HMT_361 (SP169) 0.147877623785648 0.67978345197124 0.217536368908116 0 0 TRUE Clostridiales_[G] sp._Oral_Taxon_G74 (SP170) 0.486339416888245 0.685503308299409 0.709463267354248 0 0 TRUE Fretibacterium sp._HMT_359 (SP176) -0.641381486678635 1.1766993860751 -0.545068259802508 0.585706571583861 1 FALSE Anaerolineae_[G-1] bacterium_HMT_439 (SP177) 0.432234117217782 0.73633445020067 0.587007869997102 0 0 TRUE Kingella oralis (SP178) -0.399474019311655 1.04411758847033 -0.382594856865593 0.702020184267352 1 FALSE Cardiobacterium hominis (SP18) -0.952231660013111 0.985724216012643 -0.966022386935959 0.334032978978407 1 FALSE Desulfobulbus sp._HMT_041 (SP181) 0.878308027989395 0.882839421712807 0.994867250360637 0 0 TRUE Porphyromonas pasteri (SP184) -0.696589442430131 1.00461347391621 -0.693390503428817 0.488064520302003 1 FALSE Prevotella micans (SP185) -0.6590019772029 0.854542148817455 -0.771175509733311 0.44060290828585 1 FALSE Capnocytophaga leadbetteri (SP186) -2.35941365302624 1.09413197752811 -2.1564250944906 0.0310504869278782 1 FALSE Capnocytophaga sp._HMT_336 (SP193) 0.320680421908574 0.781521047508535 0.410328580312575 0 0 TRUE Rothia dentocariosa (SP197) -1.21866157942161 1.17855794677232 -1.03402771391862 0.301123207335992 1 FALSE Fretibacterium fastidiosum (SP199) 1.0383325621693 1.14802867102042 0.904448284594133 0.365757744906453 1 FALSE Selenomonas sputigena (SP2) 2.41747684695608 1.1113960460918 2.17517135809246 0.0296172776695035 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_349 (SP204) 0.359258659678654 0.744230165485258 0.482725205641736 0 0 TRUE Porphyromonas sp._HMT_278 (SP207) 1.08696211505628 0.793765516979936 1.36937432000307 0 0 TRUE Bacteroidales_[G-2] sp._Oral_Taxon_274 (SP21) 2.55347338328833 0.905881415204214 2.81877223710644 0 0 TRUE Peptococcus sp._HMT_167 (SP210) -0.458943850409842 0.666954179402169 -0.688119011145894 0.491377839489788 1 FALSE Aggregatibacter sp._HMT_458 (SP22) -0.0559628918945081 0.505877495265818 -0.110625383453956 0 0 TRUE Bacteroidetes_[G-5] bacterium_HMT_511 (SP223) 0.979480975186384 0.95684297403568 1.02365905562877 0.305996340957816 1 FALSE Catonella sp._HMT_451 (SP225) 0.272948561350003 0.78178474460529 0.34913518488751 0 0 TRUE Selenomonas sp._HMT_134 (SP229) 0.176287835421754 0.742024061385313 0.237576979771567 0 0 TRUE Veillonella parvula (SP23) 0.129028063449498 1.3010788386538 0.0991700576599962 0.921003248165561 1 FALSE Leptotrichia shahii (SP235) 0.162772323778202 0.711003033782245 0.22893337446441 0 0 TRUE Selenomonas sp._HMT_146 (SP236) 1.03971414803562 0.935834878583984 1.11100170749012 0 0 TRUE Treponema sp._HMT_238 (SP237) 0.39994813662127 0.859973474285631 0.46507031737636 0 0 TRUE Bacteroidetes_[G-5] bacterium_HMT_505 (SP244) -1.06362359959227 0.846231350708003 -1.25689458172684 0.208791810794198 1 FALSE Lachnospiraceae_[G-3] bacterium_HMT_100 (SP247) 0.0946478935381575 0.66386208981801 0.142571619903923 0 0 TRUE Fretibacterium sp._HMT_362 (SP251) -0.226037320467078 1.02895507745611 -0.219676568413376 0.826123054612149 1 FALSE Fusobacterium sp._HMT_370 (SP255) 0.453380949701564 0.83186540533211 0.545017194843628 0 0 TRUE Abiotrophia defectiva (SP270) -1.24601548952662 1.02198516704912 -1.21921093348583 0.222764143206579 1 FALSE Fusobacterium nucleatum_subsp._animalis (SP271) 0.390685724959554 0.795536789175411 0.491096992968115 0 0 TRUE Peptostreptococcaceae_[XI][G-5] bacterium_HMT_493 (SP273) 0.272187812150442 0.7271172086388 0.374338289503547 0 0 TRUE Parvimonas micra (SP275) 0.157636391916355 0.657931075986285 0.239594081614168 0 0 TRUE Bergeyella sp._HMT_322 (SP277) -0.496235841975339 0.947944345557357 -0.523486261931939 0.600635908822017 1 FALSE Saccharibacteria_(TM7)_[G-3] bacterium_HMT_351 (SP278) -0.0465612998358124 0.588758013906908 -0.0790839338675642 0 0 TRUE Aggregatibacter paraphrophilus (SP281) 0.323720676441126 0.859845890222598 0.376486856682331 0 0 TRUE Tannerella sp._HMT_916 (SP283) -0.910982907267172 0.84783834080689 -1.0744771301569 0.282608889520317 1 FALSE Peptostreptococcus stomatis (SP287) 0.838269649733935 0.885674981500934 0.946475476041265 0 0 TRUE Syntrophomonadaceae_[VIII][G-1] bacterium_HMT_435 (SP3) 0.282270949572448 0.762897465791118 0.369998541389485 0 0 TRUE Alloprevotella sp._HMT_473 (SP306) 0.295832718592888 0.738454645466875 0.400610545832308 0 0 TRUE Clostridiales_[F-1][G-1] bacterium_HMT_093 (SP307) 0.164114625811416 0.689157090886517 0.238138195168684 0 0 TRUE Neisseria subflava (SP335) -0.655024625580156 1.04342026642894 -0.627766822875647 0.53015670306577 1 FALSE Prevotella melaninogenica (SP336) -0.187910917619128 1.13238840524194 -0.165942106744709 0.868202510454803 1 FALSE Leptotrichia sp._HMT_212 (SP338) -1.02157283398335 0.852766236278083 -1.19795178388163 0.230935788279871 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346 (SP35) -0.269196394229563 0.976874021889187 -0.275569201552684 0.782878967620723 1 FALSE Propionivibrio sp._Oral_Taxon_C33 (SP357) 0.0270093796620618 0.670752662804338 0.0402672716186304 0 0 TRUE Butyrivibrio sp._HMT_080 (SP359) 0.0616521379781555 0.641102653227405 0.0961657819816991 0 0 TRUE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_952 (SP36) 0.633470333970492 0.731415059594923 0.866088721664173 0 0 TRUE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_347 (SP362) 0.255976339573083 0.836666926015614 0.305947721385494 0 0 TRUE Porphyromonas sp._Oral_Taxon_B43 (SP366) 0.309345484423382 0.743973873994478 0.415801542549434 0 0 TRUE Prevotella intermedia (SP37) -0.433977588405332 1.41094147151373 -0.30758014926001 0.758401826993185 1 FALSE Lachnospiraceae_[G-8] bacterium_HMT_500 (SP42) 1.69133605927621 0.969101005830531 1.74526292832264 0.0809391118074091 1 FALSE Acinetobacter johnsonii (SP44) -1.83981363646383 1.39814637586882 -1.31589486495686 0.188209332522268 1 FALSE Corynebacterium matruchotii (SP47) 1.40019817062209 1.22086789952027 1.1468875307249 0.251428106807192 1 FALSE Campylobacter gracilis (SP48) 3.34788027092388 0.959069786023887 3.49075773182631 0 0 TRUE Gemella morbillorum (SP49) -1.38433225088849 1.13861971752471 -1.21579859331607 0.224061654810905 1 FALSE Treponema sp._HMT_257 (SP50) 0.153494150433105 0.683260889081905 0.224649402425704 0 0 TRUE Peptostreptococcaceae_[XI][G-4] bacterium_HMT_369 (SP54) -0.661886462018903 0.821132537694606 -0.806065320316256 0.420205186504919 1 FALSE Prevotella pleuritidis (SP55) -1.17300134447721 0.885961304873493 -1.32398710646251 0.185507326864272 1 FALSE Selenomonas artemidis (SP58) -0.94941867606325 1.06370171237967 -0.892561011243695 0.372092306282226 1 FALSE Treponema socranskii (SP59) 2.55568565600807 1.07794359554969 2.37088996730374 0.0177453130411963 1 FALSE Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP60) -0.437153699147557 0.799552462966006 -0.546747986399666 0.584551881750022 1 FALSE Bacteroidetes_[G-3] bacterium_HMT_280 (SP61) 0.0568851277763426 0.62306825304952 0.0912983890575813 0 0 TRUE Fusobacterium nucleatum_subsp._vincentii (SP63) -0.356442453082394 1.01830715913998 -0.350034319098207 0.726312941982817 1 FALSE Johnsonella sp._HMT_166 (SP64) 1.00470188859459 1.06143991011239 0.946546176587808 0.343870081617293 1 FALSE Veillonellaceae_[G-1] bacterium_HMT_129 (SP70) 1.40964226886437 0.900051932708463 1.56617881439623 0 0 TRUE Veillonellaceae_[G-1] sp._Oral_Taxon_G40 (SP72) 0.350375341767305 0.805991712519438 0.434713330577646 0 0 TRUE Peptostreptococcaceae_[XI][G-6] [Eubacterium]_nodatum (SP73) 0.319990552642227 1.0336693792093 0.309567603605518 0.756889795394251 1 FALSE Prevotella oris (SP74) -0.258826414142495 1.06761270011324 -0.242434746341105 0.808443313559136 1 FALSE Mycoplasma faucium (SP75) -0.0366776018652673 0.8477322261941 -0.0432655509982576 0.96548985181612 1 FALSE Selenomonas sp._HMT_126 (SP79) 0.323866532115472 0.754195101952199 0.429420094717082 0 0 TRUE Acinetobacter sp._Oral_Taxon_A58 (SP83) -3.94189191320179 1.19406674796458 -3.30123246453449 0.000962610898438092 0.147279467461028 FALSE Filifactor alocis (SP84) 1.40800326792912 0.986684438439426 1.42700463600709 0.15357855834226 1 FALSE Bacteroidetes_[G-3] bacterium_HMT_503 (SP87) -0.982504735237162 0.722747135472189 -1.35940315362892 0.174018872342248 1 FALSE Sphingobium yanoikuyae (SP88) -3.31147665006567 1.39836767266171 -2.36810154783002 0.0178796277053603 1 FALSE Prevotella nigrescens (SP9) 0.0773937580622009 1.29783502864104 0.059632970565789 0.952447958372184 1 FALSE Acidovorax temperans (SP96) -2.92686654657939 1.62291126091443 -1.8034667803896 0.0713149380108639 1 FALSE Streptococcus anginosus (SP98) -1.28744558381786 1.17742468709071 -1.093441982263 0.274199789238066 1 FALSE Saccharibacteria_(TM7)_[G-1] bacterium_HMT_346_nov_97.968% (SPN10) 0.902734665172737 0.876722194318655 1.02967014069297 0 0 TRUE Prevotella nigrescens_nov_96.739% (SPN13) 0.0794821292250343 0.705638029088987 0.112638670180021 0.9103170257565 1 FALSE Treponema sp._HMT_927_nov_94.839% (SPN14) -0.288250974023352 0.938954537064688 -0.306991406553577 0.758849913189616 1 FALSE Arachnia propionica_nov_97.768% (SPN30) 0.382332462341549 0.822317067700763 0.464945308031327 0 0 TRUE Pseudomonas alcaliphila_chengduensis_mendocina_oleovorans_toyo ...(5 species) (SPP100) -3.01442621325925 1.63851878134985 -1.83972637211756 0.0658084197337708 1 FALSE Selenomonas sp._HMT_138_sp._HMT_892 (SPP11) 1.95898680877113 0.934776489633558 2.09567402528392 0 0 TRUE Lautropia dentalis_mirabilis (SPP13) -0.0330835515534914 1.24527424487332 -0.0265672816166345 0.978804869531007 1 FALSE Streptococcus sanguinis_sp._Oral_Taxon_B66 (SPP14) -3.48579881513044 1.30303347240031 -2.67514142112502 0 0 TRUE Agrobacterium_Beijerinckia_Rhizobium fluminensis_nepotum_tumefaciens (SPP17) -1.30556048296566 1.01190781579406 -1.29019705410731 0.196982248723507 1 FALSE Fusobacterium canifelinum_nucleatum_nucleatum_ss_polymorphum_nuc ...(5 species) (SPP20) -0.543704010277794 0.718370085151774 -0.756857811197584 0.44913505328149 1 FALSE Veillonella denticariosi_parvula_tobetsuensis (SPP25) 0.238569221273055 0.783599232701013 0.304453107299152 0 0 TRUE Oribacterium sp._HMT_078_sp._Oral_Taxon_78 (SPP33) 0.724796749545552 0.76496385196011 0.947491502622464 0 0 TRUE Catonella morbi_sp._HMT_164 (SPP35) -0.447136562846701 0.943516902362167 -0.473904136457185 0.635568269362028 1 FALSE Capnocytophaga endodontalis_sp._HMT_326 (SPP36) 0.788725389582466 0.854344781137883 0.923193313748554 0 0 TRUE Streptococcus cristatus_gwangjuense_infantis_infantis_clade_431_ ...(20 species) (SPP4) -2.10376363468153 1.65728316656898 -1.26940505830207 0.204296633020036 1 FALSE Leptotrichia_Pseudoleptotrichia goodfellowii (SPP40) 0.0952545688063813 0.758469747604908 0.125587828792349 0 0 TRUE Veillonella dispar_parvula (SPP41) -0.0136239029377799 1.39101705542321 -0.00979420265529018 0.992185481852609 1 FALSE Neisseria oralis_sp._Oral_Taxon_14 (SPP47) -1.91146429359122 0.899968177967109 -2.12392431242283 0.0336764730343195 1 FALSE Aggregatibacter segnis_sp._HMT_512 (SPP49) 1.26174106630677 0.838770898660454 1.5042737752607 0 0 TRUE Fusobacterium nucleatum_nucleatum_subsp._animalis (SPP52) -0.836800882345894 0.694864972096912 -1.20426401667745 0.228487549862752 1 FALSE Cutibacterium_Propionibacterium acnes_sp._str._LG (SPP57) -2.59621028854547 1.20409807492289 -2.15614520329811 0 0 TRUE Eubacterium_[XI][G-7]_Peptoanaerobacter_Peptostreptococcaceae_[XI][G-7] [Eubacterium] yurii_[Eubacterium]_yurii_subsps._yurii_&_margaretiae_yurii (SPP58) 0.87589046137044 1.27546764468609 0.686721035237243 0.492258538701008 1 FALSE Streptococcus cristatus_cristatus_clade_578 (SPP6) -1.19289082585336 0.813184757422032 -1.46693702134196 0.14239318834444 1 FALSE Pseudomonas fildesensis_veronii (SPP60) -2.79898968589951 1.34297275760694 -2.08417458213155 0 0 TRUE Veillonellaceae_[G-1] bacterium_HMT_132_bacterium_HMT_150 (SPP61) -1.06324911358132 0.814260301147352 -1.30578527785663 0.191625587964405 1 FALSE Selenomonas sp._HMT_134_sputigena (SPP63) 0.359581839084964 0.746413463252539 0.481746185978567 0 0 TRUE Neisseria flavescens_flavescens|subflava (SPP65) -0.106437549663469 0.549920966626008 -0.193550630223298 0 0 TRUE Neisseria flava_macacae_mucosa_sicca_sp._TM101 (SPP69) 0.564158317094962 1.25720396675041 0.448740484452322 0.653618876383053 1 FALSE Paraburkholderia caledonica_fungorum_strydomiana (SPP70) -3.2860291446227 1.25375918291185 -2.62094123768721 0 0 TRUE Peptostreptococcaceae_[XI][G-7]_unclassified_Peptostreptococcaceae Oral_sp._str._CM5_bacterium_HMT_081 (SPP78) -1.04957216770795 0.681536740388196 -1.540008198399 0.123558355034885 1 FALSE Porphyromonas catoniae_sp._HMT_275_sp._HMT_284 (SPP79) 1.21727629627223 0.863801564082327 1.40920825671973 0 0 TRUE Lachnoanaerobaculum gingivalis_umeaense (SPP80) -0.494744443953313 1.118449597578 -0.442348448266852 0.658237077296753 1 FALSE Porphyromonas catoniae_sp._HMT_284 (SPP81) -1.29601533843282 0.819787034696615 -1.58091709624616 0.113896994750021 1 FALSE Fusobacterium nucleatum_nucleatum_ss_vincentii (SPP87) 0.177888818327503 0.702917347069632 0.253072169962937 0 0 TRUE Fusobacterium nucleatum_nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP88) -1.02138467245024 0.917732581886142 -1.11294367510749 0.265732620764926 1 FALSE Fusobacterium naviforme_nucleatum_nucleatum_ss_animalis_nucleatu ...(5 species) (SPP89) -1.1652922114925 0.62790687917813 -1.85583603259412 0.0634769329020552 1 FALSE Fusobacterium nucleatum_nucleatum_subsp._vincentii (SPP90) 0.12875285330831 1.05252267101975 0.122327866993654 0.902639363057585 1 FALSE Fusobacterium nucleatum_nucleatum_ss_nucleatum_nucleatum_subsp._nucleatum (SPP91) 0.515700423523239 0.928465996857408 0.555432751731068 0 0 TRUE Fusobacterium nucleatum_nucleatum_ss_animalis (SPP92) -0.571819839653443 1.25807757012112 -0.454518746088441 0.649455502531039 1 FALSE Fusobacterium nucleatum_ss_vincentii_nucleatum_subsp._vincentii (SPP94) -0.151319436845938 1.03332553403852 -0.146439269969978 0.883574628482532 1 FALSE Granulicatella adiacens_paradiacens (SPP96) -2.64116603291556 1.22443768834312 -2.15704405218818 0 0 TRUE Campylobacter rectus_showae (SPP97) 1.79151738505106 1.08959543439767 1.6442041958825 0.100134030543183 1 FALSE Selenomonas infelix_sp._HMT_479_sp._HMT_481 (SPP98) 0.688095806406566 0.815058828179358 0.844228395076222 0 0 TRUE