K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Erysipelatoclostridium.S_ramosum 4.278733327724799 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Mammaliicoccus.S_lentus 4.772094529586975 WT_Tooth+Lig+IgG 4.490478967233396 0.007616533148713935 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Corynebacteriales.F_Corynebacteriaceae.G_Corynebacterium.S_lowii 5.212193655651761 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_faecalis 5.702598843325122 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Weissella.S_paramesenteroides 5.178476027116726 DB_Control 4.862276426402369 5.871826896391104e-05 K_Bacteria.P_Verrucomicrobia.C_Verrucomicrobiae.O_Verrucomicrobiales.F_Akkermansiaceae.G_Akkermansia.S_muciniphila 3.206793207693054 WT_Control 2.892833365468506 0.038327278922072515 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Pantoea.S_conspicua 3.6544795354419675 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Klebsiella.S_variicola 4.802638425156734 DB_Tooth+Lig+anti_IL17 4.465073425229711 0.0459332278691278 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Pantoea.S_dispersa 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Staphylococcus.S_ureilyticus 3.155985009382931 WT_Control 2.9711164650707036 0.0007942445996529516 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Lactobacillus.S_johnsonii 5.374731423384561 DB_Tooth+Lig+IgG 5.1341266148755125 0.002285229295202718 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Mammaliicoccus.S_sciuri 3.9987756407768873 - K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Corynebacteriales.F_Corynebacteriaceae.G_Corynebacterium.S_tuberculostearicum 2.173213103298496 WT_Control 2.494652820905783 0.005863543984964819 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Pantoea.S_brenneri 3.28485259414625 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Staphylococcus.S_capitis 3.924547854018689 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Dubosiella.S_newyorkensis 3.958316082674989 WT_Control 3.64100492413678 0.0001665142798518962 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Enterobacter.S_mori 5.1177651593741045 WT_Tooth+Lig+anti_IL17 4.7726145438534715 0.010141203402847757 K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Peptostreptococcaceae.G_Romboutsia.S_timonensis 3.313791049105451 WT_Control 3.049945255554034 6.569801868036882e-05 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Klebsiella.S_pneumoniae 3.9424401117380157 DB_Tooth+Lig+anti_IL17 3.5916329752584653 0.0459332278691278 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Carnobacteriaceae.G_Atopostipes.S_sp__MOT_201 3.4485825779174553 WT_Control 3.178570759949196 0.00015378921174533146 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Mixta.S_calida 4.802837435175647 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Faecalibaculum.S_rodentium 2.5471979034961896 WT_Control 2.5099890223814247 0.013013636393374297 K_Bacteria.P_Bacteroidetes.C_Bacteroidia.O_Bacteroidales.F_Muribaculaceae.G_Muribaculaceae__G_2_.S_bacterium_MOT_104_nov_90_802 4.332309721323283 DB_Control 4.104524474662701 2.1344209542980517e-06 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Planococcaceae.G_Sporosarcina.S_siberiensis_nov_97_892 0.0 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Turicibacteraceae.G_Turicibacter.S_sanguinis_nov_96_262 4.160326358750153 DB_Control 3.946874787239004 0.0010905569275601427 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Weissella.S_paramesenteroides_nov_94_614 4.091584404985806 DB_Control 3.794288925349457 8.904922888601998e-05 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_faecalis_nov_94_614 4.00948302304259 DB_Control 3.704278942847828 0.00015685197850775847 K_Bacteria.P_Bacteroidetes.C_Bacteroidia.O_Bacteroidales.F_Muribaculaceae.G_Muribaculaceae__G_2_.S_bacterium_MOT_104_nov_89_810 3.2495144341485465 DB_Control 3.045604209679302 0.0003182426416283257 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_faecalis_nov_97_424 1.6318073072164665 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_faecalis_nov_94_626 4.290544154429747 DB_Control 4.00238210478772 0.0020811363752172986 K_Bacteria.P_Cyanobacteria.C_Gloeobacteria.O_Gloeobacterales.F_Gloeobacteraceae.G_Gloeobacter.S_kilaueensis_nov_81_638 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Lactobacillus.S_johnsonii_nov_94_626 4.230081400487001 DB_Control 3.91917063118948 0.013002750368710339 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_multispecies_spp12_2 5.651102325277935 WT_Tooth+Lig+IgG 5.342476004251524 0.0018765616009083815 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_multifamily.G_multigenus.S_multispecies_spp143_4 5.399846503139603 DB_Tooth+Lig+anti_IL17 5.090824792989516 0.006173344274481641 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Limosilactobacillus.S_multispecies_spp16_2 3.851607195955884 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_multigenus.S_multispecies_spp21_6 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Enterobacter.S_multispecies_spp22_4 5.0018074576996865 WT_Tooth+Lig+anti_IL17 4.656759071467591 0.040947729034806674 K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Clostridiaceae.G_Clostridium.S_multispecies_spp28_2 2.5328607217768107 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_multispecies_spp29_5 2.4230218925469122 DB_Control 2.619426748260184 0.001388453059225473 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Kluyvera.S_multispecies_spp39_2 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_multigenus.S_multispecies_spp41_2 0.0 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Lachnospiraceae.G_Blautia.S_multispecies_spp48_3 2.529009350658499 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_multispecies_spp57_3 4.277920943148596 DB_Tooth+Lig+anti_IL17 4.007631932032031 0.006594212052061 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Staphylococcus.S_multispecies_spp59_3 4.711447555724744 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Klebsiella.S_multispecies_spp71_2 3.981316665990998 DB_Tooth+Lig+anti_IL17 3.6247267446682696 0.0459332278691278 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Enterobacter.S_multispecies_spp72_2 5.16578770340354 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_multifamily.G_multigenus.S_multispecies_spp76_2 2.776341398811957 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Staphylococcus.S_multispecies_spp82_2 4.328291171814343 WT_Tooth+Lig+anti_IL17 3.914509403263907 0.001484487101422312 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Bifidobacteriales.F_Bifidobacteriaceae.G_Bifidobacterium.S_multispecies_spp96_2 5.3143328014222595 WT_Control 5.001516642604845 0.007339513381871844 K_Bacteria.P_Proteobacteria.C_Alphaproteobacteria.O_Hyphomicrobiales.F_Parvibaculaceae.G_Rhodoligotrophos.S_multispecies_sppn5_2_nov_78_502 2.7092122385291297 WT_Control 2.562592889709453 4.192583817452245e-07 K_Bacteria 5.999999999999999 - K_Bacteria.P_Firmicutes 5.9382799870183565 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia 4.309319049651034 WT_Tooth+Lig+IgG 4.070876926794129 0.0015643632014573521 K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales 4.309319049651034 WT_Tooth+Lig+IgG 4.0708073174223784 0.0015643632014573521 K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae 4.27879978868852 WT_Tooth+Lig+IgG 4.061566702393919 0.013827822594868592 K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Erysipelatoclostridium 4.278733327724799 - K_Bacteria.P_Firmicutes.C_Bacilli 5.930598814042088 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales 5.084006971489725 WT_Tooth+Lig+IgG 4.783714891709519 0.016226665806884547 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae 5.084006971489725 WT_Tooth+Lig+IgG 4.783711096327978 0.016226665806884547 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Mammaliicoccus 4.772094529586975 WT_Tooth+Lig+IgG 4.453918000078187 0.011282035284419642 K_Bacteria.P_Actinobacteria 5.567464252001912 WT_Control 5.241123797518451 0.04048796814115598 K_Bacteria.P_Actinobacteria.C_Actinomycetia 5.567464252001912 WT_Control 5.240992582605704 0.04048796814115598 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Corynebacteriales 5.212590486411491 WT_Control 4.872197243160404 0.04411275420453701 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Corynebacteriales.F_Corynebacteriaceae 5.212590486411491 WT_Control 4.872197227622509 0.04411275420453701 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Corynebacteriales.F_Corynebacteriaceae.G_Corynebacterium 5.212590486411491 WT_Control 4.872197222274473 0.04411275420453701 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales 5.929508069100666 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae 5.789243062789053 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus 5.789243062789053 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae 5.499612021216544 DB_Control 5.2087565701123175 0.0019987962293303795 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Weissella 5.212649863205546 DB_Control 4.897791934820876 5.636958637055519e-05 K_Bacteria.P_Verrucomicrobia 3.206793207693054 WT_Control 2.895337723896867 0.038327278922072515 K_Bacteria.P_Verrucomicrobia.C_Verrucomicrobiae 3.206793207693054 WT_Control 2.8922454433203173 0.038327278922072515 K_Bacteria.P_Verrucomicrobia.C_Verrucomicrobiae.O_Verrucomicrobiales 3.206793207693054 WT_Control 2.895695823558367 0.038327278922072515 K_Bacteria.P_Verrucomicrobia.C_Verrucomicrobiae.O_Verrucomicrobiales.F_Akkermansiaceae 3.206793207693054 WT_Control 2.891302358026075 0.038327278922072515 K_Bacteria.P_Verrucomicrobia.C_Verrucomicrobiae.O_Verrucomicrobiales.F_Akkermansiaceae.G_Akkermansia 3.206793207693054 WT_Control 2.8937654469705105 0.038327278922072515 K_Bacteria.P_Proteobacteria 5.712479567716114 DB_Tooth+Lig+anti_IL17 5.306292974081319 0.011919030656704929 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria 5.712479567716114 DB_Tooth+Lig+anti_IL17 5.30629297377926 0.011919030656704929 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales 5.712479567716114 DB_Tooth+Lig+anti_IL17 5.30629297377926 0.011919030656704929 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae 4.844783586006577 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Pantoea 3.80888710664084 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae 5.485316425193846 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Klebsiella 4.9128480747297125 DB_Tooth+Lig+anti_IL17 4.553800461501447 0.0459332278691278 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Staphylococcus 4.79359338506631 WT_Tooth+Lig+IgG 4.497403956093506 0.008237206955949938 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Lactobacillus 5.390605182734909 DB_Tooth+Lig+IgG 5.14894274251735 0.0025300868977004677 K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Dubosiella 3.958316082674989 WT_Control 3.6411194576142623 0.0001665142798518962 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Enterobacter 5.485316425193846 - K_Bacteria.P_Firmicutes.C_Clostridia 3.3575275600194807 WT_Control 3.0792983912529506 0.022086649693398745 K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales 3.3575275600194807 WT_Control 3.078751954758013 0.022086649693398745 K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Peptostreptococcaceae 3.313791049105451 WT_Control 3.0485817906427277 6.569801868036882e-05 K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Peptostreptococcaceae.G_Romboutsia 3.313791049105451 WT_Control 3.0494664421191513 6.569801868036882e-05 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Carnobacteriaceae 3.4485825779174553 WT_Control 3.1785755156745834 0.00015378921174533146 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Carnobacteriaceae.G_Atopostipes 3.4485825779174553 WT_Control 3.1785690085978153 0.00015378921174533146 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Mixta 4.802837435175647 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Faecalibaculum 2.5471979034961896 WT_Control 2.505786525655141 0.013013636393374297 K_Bacteria.P_Bacteroidetes 4.366794889658498 DB_Control 4.139563941878964 4.248522466788226e-06 K_Bacteria.P_Bacteroidetes.C_Bacteroidia 4.366794889658498 DB_Control 4.139563891762955 4.248522466788226e-06 K_Bacteria.P_Bacteroidetes.C_Bacteroidia.O_Bacteroidales 4.366794889658498 DB_Control 4.139563913632245 4.248522466788226e-06 K_Bacteria.P_Bacteroidetes.C_Bacteroidia.O_Bacteroidales.F_Muribaculaceae 4.366794889658498 DB_Control 4.139563958107199 4.248522466788226e-06 K_Bacteria.P_Bacteroidetes.C_Bacteroidia.O_Bacteroidales.F_Muribaculaceae.G_Muribaculaceae__G_2_ 4.366794889658498 DB_Control 4.139563976389726 4.248522466788226e-06 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Planococcaceae 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Planococcaceae.G_Sporosarcina 0.0 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Turicibacteraceae 4.160326358750153 DB_Control 3.946849465341533 0.0010905569275601427 K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Turicibacteraceae.G_Turicibacter 4.160326358750153 DB_Control 3.946845438383772 0.0010905569275601427 K_Bacteria.P_Cyanobacteria 0.0 - K_Bacteria.P_Cyanobacteria.C_Gloeobacteria 0.0 - K_Bacteria.P_Cyanobacteria.C_Gloeobacteria.O_Gloeobacterales 0.0 - K_Bacteria.P_Cyanobacteria.C_Gloeobacteria.O_Gloeobacterales.F_Gloeobacteraceae 0.0 - K_Bacteria.P_Cyanobacteria.C_Gloeobacteria.O_Gloeobacterales.F_Gloeobacteraceae.G_Gloeobacter 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_multifamily 5.399846503139603 DB_Tooth+Lig+anti_IL17 5.091583586293535 0.006321306732438579 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_multifamily.G_multigenus 5.399846503139603 DB_Tooth+Lig+anti_IL17 5.091533026413628 0.006321306732438579 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Limosilactobacillus 3.851607195955884 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_multigenus 0.0 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Clostridiaceae 2.5328607217768107 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Clostridiaceae.G_Clostridium 2.5328607217768107 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Kluyvera 0.0 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Lachnospiraceae 2.529009350658499 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Lachnospiraceae.G_Blautia 2.529009350658499 - K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Bifidobacteriales 5.3143328014222595 WT_Control 5.001165380102628 0.007339513381871844 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Bifidobacteriales.F_Bifidobacteriaceae 5.3143328014222595 WT_Control 5.001325008946806 0.007339513381871844 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Bifidobacteriales.F_Bifidobacteriaceae.G_Bifidobacterium 5.3143328014222595 WT_Control 5.0013243085622765 0.007339513381871844 K_Bacteria.P_Proteobacteria.C_Alphaproteobacteria 2.7092122385291297 WT_Control 2.560803768641136 4.192583817452245e-07 K_Bacteria.P_Proteobacteria.C_Alphaproteobacteria.O_Hyphomicrobiales 2.7092122385291297 WT_Control 2.56126488902471 4.192583817452245e-07 K_Bacteria.P_Proteobacteria.C_Alphaproteobacteria.O_Hyphomicrobiales.F_Parvibaculaceae 2.7092122385291297 WT_Control 2.5614674272643496 4.192583817452245e-07 K_Bacteria.P_Proteobacteria.C_Alphaproteobacteria.O_Hyphomicrobiales.F_Parvibaculaceae.G_Rhodoligotrophos 2.7092122385291297 WT_Control 2.5611148458238495 4.192583817452245e-07