K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Erysipelatoclostridium.S_ramosum 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Mammaliicoccus.S_lentus 2.7577947076735274 WT_Control 3.157451115681329 0.01116399431224871 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Corynebacteriales.F_Corynebacteriaceae.G_Corynebacterium.S_lowii 5.212193655651761 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_faecalis 5.357372609887252 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Weissella.S_paramesenteroides 2.5198860871787003 - K_Bacteria.P_Verrucomicrobia.C_Verrucomicrobiae.O_Verrucomicrobiales.F_Akkermansiaceae.G_Akkermansia.S_muciniphila 3.206793207693054 WT_Control 3.0540396134786225 0.02157174794772086 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Pantoea.S_conspicua 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Klebsiella.S_variicola 4.802638425156734 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Pantoea.S_dispersa 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Staphylococcus.S_ureilyticus 3.155985009382931 WT_Control 3.321909764162957 0.002822315299486481 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Lactobacillus.S_johnsonii 5.269361545044578 WT_Control 4.9813197161502325 0.004075200091520405 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Mammaliicoccus.S_sciuri 3.9987756407768873 - K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Corynebacteriales.F_Corynebacteriaceae.G_Corynebacterium.S_tuberculostearicum 2.173213103298496 WT_Control 3.202592275824505 0.03662753490958964 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Pantoea.S_brenneri 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Staphylococcus.S_capitis 0.0 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Dubosiella.S_newyorkensis 3.958316082674989 WT_Control 3.627960952167631 0.005062032126267864 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Enterobacter.S_mori 4.307661527310092 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Peptostreptococcaceae.G_Romboutsia.S_timonensis 3.313791049105451 WT_Control 3.158266369599798 0.004075200091520405 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Klebsiella.S_pneumoniae 3.9424401117380157 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Carnobacteriaceae.G_Atopostipes.S_sp__MOT_201 3.4485825779174553 WT_Control 3.200029468390524 0.01116399431224871 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Mixta.S_calida 0.0 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Faecalibaculum.S_rodentium 2.5471979034961896 - K_Bacteria.P_Bacteroidetes.C_Bacteroidia.O_Bacteroidales.F_Muribaculaceae.G_Muribaculaceae__G_2_.S_bacterium_MOT_104_nov_90_802 4.185558591881434 WT_Control 3.8333216178748364 0.002822315299486481 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Planococcaceae.G_Sporosarcina.S_siberiensis_nov_97_892 0.0 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Turicibacteraceae.G_Turicibacter.S_sanguinis_nov_96_262 2.4250110511616256 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Weissella.S_paramesenteroides_nov_94_614 1.8392648909434017 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_faecalis_nov_94_614 1.7560107506385947 - K_Bacteria.P_Bacteroidetes.C_Bacteroidia.O_Bacteroidales.F_Muribaculaceae.G_Muribaculaceae__G_2_.S_bacterium_MOT_104_nov_89_810 1.6099895720252582 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_faecalis_nov_97_424 0.9765582210095235 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_faecalis_nov_94_626 4.172594882581851 WT_Control 3.8825750408302535 0.008891734638124307 K_Bacteria.P_Cyanobacteria.C_Gloeobacteria.O_Gloeobacterales.F_Gloeobacteraceae.G_Gloeobacter.S_kilaueensis_nov_81_638 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Lactobacillus.S_johnsonii_nov_94_626 4.095191223313304 WT_Control 3.7959008685526947 0.012799113720245552 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_multispecies_spp12_2 5.361536605595922 DB_Tooth+Lig+anti_IL17 5.1270995756898685 0.031633423039876915 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_multifamily.G_multigenus.S_multispecies_spp143_4 5.399846503139603 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Limosilactobacillus.S_multispecies_spp16_2 3.851607195955884 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_multigenus.S_multispecies_spp21_6 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Enterobacter.S_multispecies_spp22_4 4.2065363056177985 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Clostridiaceae.G_Clostridium.S_multispecies_spp28_2 2.5328607217768107 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_multispecies_spp29_5 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Kluyvera.S_multispecies_spp39_2 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_multigenus.S_multispecies_spp41_2 0.0 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Lachnospiraceae.G_Blautia.S_multispecies_spp48_3 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus.S_multispecies_spp57_3 4.277920943148596 DB_Tooth+Lig+anti_IL17 4.138910319008219 0.04268018381389434 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Staphylococcus.S_multispecies_spp59_3 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Klebsiella.S_multispecies_spp71_2 3.981316665990998 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Enterobacter.S_multispecies_spp72_2 5.16578770340354 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_multifamily.G_multigenus.S_multispecies_spp76_2 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Staphylococcus.S_multispecies_spp82_2 4.1841481645851095 WT_Control 3.8895741607399503 0.005062032126267864 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Bifidobacteriales.F_Bifidobacteriaceae.G_Bifidobacterium.S_multispecies_spp96_2 5.3143328014222595 WT_Control 4.9733789599079286 0.008891734638124307 K_Bacteria.P_Proteobacteria.C_Alphaproteobacteria.O_Hyphomicrobiales.F_Parvibaculaceae.G_Rhodoligotrophos.S_multispecies_sppn5_2_nov_78_502 2.7092122385291297 WT_Control 3.094168552077904 0.002822315299486481 K_Bacteria 5.999999999999999 - K_Bacteria.P_Firmicutes 5.690763138458411 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia 3.9869250823794955 WT_Control 3.676168729165118 0.008891734638124307 K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales 3.9869250823794955 WT_Control 3.6762663837033873 0.008891734638124307 K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae 3.9748498948324134 WT_Control 3.6635924346418176 0.005062032126267864 K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Erysipelatoclostridium 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli 5.680026158913322 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales 4.435484180907496 WT_Control 4.161261074185154 0.005062032126267864 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae 4.435484180907496 WT_Control 4.161267669058431 0.005062032126267864 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Mammaliicoccus 4.0230207653953824 WT_Control 3.849376979650927 0.004075200091520405 K_Bacteria.P_Actinobacteria 5.567464252001912 WT_Control 5.260030776678541 0.01041109814711044 K_Bacteria.P_Actinobacteria.C_Actinomycetia 5.567464252001912 WT_Control 5.260030776678541 0.01041109814711044 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Corynebacteriales 5.212590486411491 - K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Corynebacteriales.F_Corynebacteriaceae 5.212590486411491 - K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Corynebacteriales.F_Corynebacteriaceae.G_Corynebacterium 5.212590486411491 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales 5.669514791817785 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae 5.668583285677534 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Enterococcaceae.G_Enterococcus 5.668583285677534 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae 5.313512197678683 WT_Control 5.025281227710991 0.005062032126267864 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Weissella 2.53169303922962 - K_Bacteria.P_Verrucomicrobia 3.206793207693054 WT_Control 3.050258137677196 0.02157174794772086 K_Bacteria.P_Verrucomicrobia.C_Verrucomicrobiae 3.206793207693054 WT_Control 3.042148639349499 0.02157174794772086 K_Bacteria.P_Verrucomicrobia.C_Verrucomicrobiae.O_Verrucomicrobiales 3.206793207693054 WT_Control 3.048146563251204 0.02157174794772086 K_Bacteria.P_Verrucomicrobia.C_Verrucomicrobiae.O_Verrucomicrobiales.F_Akkermansiaceae 3.206793207693054 WT_Control 3.044696028597444 0.02157174794772086 K_Bacteria.P_Verrucomicrobia.C_Verrucomicrobiae.O_Verrucomicrobiales.F_Akkermansiaceae.G_Akkermansia 3.206793207693054 WT_Control 3.052029292211878 0.02157174794772086 K_Bacteria.P_Proteobacteria 5.712479567716114 DB_Tooth+Lig+anti_IL17 5.27662232592991 0.028459736916310582 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria 5.712479567716114 DB_Tooth+Lig+anti_IL17 5.277293445857575 0.028459736916310582 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales 5.712479567716114 DB_Tooth+Lig+anti_IL17 5.277293445857575 0.028459736916310582 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Pantoea 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae 5.422750690875321 DB_Tooth+Lig+anti_IL17 5.05881456202576 0.017622090962324435 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Klebsiella 4.9128480747297125 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Staphylococcaceae.G_Staphylococcus 4.223054709537114 WT_Control 3.9270441251353465 0.005062032126267864 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Lactobacillus 5.297510576471043 WT_Control 5.007630099133994 0.004075200091520405 K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Dubosiella 3.958316082674989 WT_Control 3.6275857641279674 0.005062032126267864 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Enterobacter 5.262166608865802 DB_Tooth+Lig+anti_IL17 4.768785668796192 0.04460971802493963 K_Bacteria.P_Firmicutes.C_Clostridia 3.3575275600194807 WT_Control 3.270174944080482 0.03517486059787196 K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales 3.3575275600194807 WT_Control 3.2532816844433285 0.03517486059787196 K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Peptostreptococcaceae 3.313791049105451 WT_Control 3.1580021197752908 0.004075200091520405 K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Peptostreptococcaceae.G_Romboutsia 3.313791049105451 WT_Control 3.1581658042657814 0.004075200091520405 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Carnobacteriaceae 3.4485825779174553 WT_Control 3.2000292511413018 0.01116399431224871 K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Carnobacteriaceae.G_Atopostipes 3.4485825779174553 WT_Control 3.2000309651067123 0.01116399431224871 K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Erwiniaceae.G_Mixta 0.0 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Erysipelotrichaceae.G_Faecalibaculum 2.5471979034961896 - K_Bacteria.P_Bacteroidetes 4.1867110865278825 WT_Control 3.834928125932206 0.002822315299486481 K_Bacteria.P_Bacteroidetes.C_Bacteroidia 4.1867110865278825 WT_Control 3.8349280455682306 0.002822315299486481 K_Bacteria.P_Bacteroidetes.C_Bacteroidia.O_Bacteroidales 4.1867110865278825 WT_Control 3.8349283241518997 0.002822315299486481 K_Bacteria.P_Bacteroidetes.C_Bacteroidia.O_Bacteroidales.F_Muribaculaceae 4.1867110865278825 WT_Control 3.8349279035520656 0.002822315299486481 K_Bacteria.P_Bacteroidetes.C_Bacteroidia.O_Bacteroidales.F_Muribaculaceae.G_Muribaculaceae__G_2_ 4.1867110865278825 WT_Control 3.834927873005135 0.002822315299486481 K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Planococcaceae 0.0 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Bacillales.F_Planococcaceae.G_Sporosarcina 0.0 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Turicibacteraceae 2.4250110511616256 - K_Bacteria.P_Firmicutes.C_Erysipelotrichia.O_Erysipelotrichales.F_Turicibacteraceae.G_Turicibacter 2.4250110511616256 - K_Bacteria.P_Cyanobacteria 0.0 - K_Bacteria.P_Cyanobacteria.C_Gloeobacteria 0.0 - K_Bacteria.P_Cyanobacteria.C_Gloeobacteria.O_Gloeobacterales 0.0 - K_Bacteria.P_Cyanobacteria.C_Gloeobacteria.O_Gloeobacterales.F_Gloeobacteraceae 0.0 - K_Bacteria.P_Cyanobacteria.C_Gloeobacteria.O_Gloeobacterales.F_Gloeobacteraceae.G_Gloeobacter 0.0 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_multifamily 5.399846503139603 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_multifamily.G_multigenus 5.399846503139603 - K_Bacteria.P_Firmicutes.C_Bacilli.O_Lactobacillales.F_Lactobacillaceae.G_Limosilactobacillus 3.851607195955884 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_multigenus 0.0 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Clostridiaceae 2.5328607217768107 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Clostridiaceae.G_Clostridium 2.5328607217768107 - K_Bacteria.P_Proteobacteria.C_Gammaproteobacteria.O_Enterobacterales.F_Enterobacteriaceae.G_Kluyvera 0.0 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Lachnospiraceae 0.0 - K_Bacteria.P_Firmicutes.C_Clostridia.O_Eubacteriales.F_Lachnospiraceae.G_Blautia 0.0 - K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Bifidobacteriales 5.3143328014222595 WT_Control 4.973705175324542 0.008891734638124307 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Bifidobacteriales.F_Bifidobacteriaceae 5.3143328014222595 WT_Control 4.973551127899629 0.008891734638124307 K_Bacteria.P_Actinobacteria.C_Actinomycetia.O_Bifidobacteriales.F_Bifidobacteriaceae.G_Bifidobacterium 5.3143328014222595 WT_Control 4.97355570847358 0.008891734638124307 K_Bacteria.P_Proteobacteria.C_Alphaproteobacteria 2.7092122385291297 WT_Control 3.0938741539888253 0.002822315299486481 K_Bacteria.P_Proteobacteria.C_Alphaproteobacteria.O_Hyphomicrobiales 2.7092122385291297 WT_Control 3.094059419991534 0.002822315299486481 K_Bacteria.P_Proteobacteria.C_Alphaproteobacteria.O_Hyphomicrobiales.F_Parvibaculaceae 2.7092122385291297 WT_Control 3.0941074760784484 0.002822315299486481 K_Bacteria.P_Proteobacteria.C_Alphaproteobacteria.O_Hyphomicrobiales.F_Parvibaculaceae.G_Rhodoligotrophos 2.7092122385291297 WT_Control 3.0940914517481772 0.002822315299486481