Percentile	0.0	25.0	50.0	75.0	100.0	0.0	25.0	50.0	75.0	100.0	0.0	25.0	50.0	75.0	100.0	0.0	25.0	50.0	75.0	100.0	0.0	25.0	50.0	75.0	100.0	0.0	25.0	50.0	75.0	100.0
Group	DB_Control	DB_Control	DB_Control	DB_Control	DB_Control	DB_Imp+Lig+IgG	DB_Imp+Lig+IgG	DB_Imp+Lig+IgG	DB_Imp+Lig+IgG	DB_Imp+Lig+IgG	DB_Imp+Lig+anti_IL17	DB_Imp+Lig+anti_IL17	DB_Imp+Lig+anti_IL17	DB_Imp+Lig+anti_IL17	DB_Imp+Lig+anti_IL17	WT_Control	WT_Control	WT_Control	WT_Control	WT_Control	WT_Imp+Lig+IgG	WT_Imp+Lig+IgG	WT_Imp+Lig+IgG	WT_Imp+Lig+IgG	WT_Imp+Lig+IgG	WT_Imp+Lig+anti_IL17	WT_Imp+Lig+anti_IL17	WT_Imp+Lig+anti_IL17	WT_Imp+Lig+anti_IL17	WT_Imp+Lig+anti_IL17
Erysipelatoclostridium ramosum (SP168)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	38.5	12955.0	1.0	1.0	1.0	1.0	1.0
Mammaliicoccus lentus (SP171)	1.0	1.0	1.0	1.0	13.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	15.0	21.0	21.0	137.0	1.0	1.0	1.0	1.0	16953.0	1.0	1.0	1.0	1.0	3.0
Corynebacterium lowii (SP191)	1.0	1.0	1.0	3.25	6.0	5.0	200.0	1578.0	2944.75	4486.0	1.0	1.0	1.5	4.5	12.0	1.0	1.0	45.0	84.0	111777.0	1.0	1.0	1.0	19.75	7234.0	1.0	1.0	1.0	6.25	94.0
Enterococcus faecalis (SP2)	8857.0	27214.25	30200.5	38191.5	43855.0	1.0	238.5	755.5	22832.75	38638.0	249.0	13273.5	30481.0	51909.75	77598.0	327.0	2611.0	20268.0	20838.0	28108.0	5.0	85.0	981.5	13186.5	94852.0	1.0	1503.75	6527.5	30857.0	45332.0
Weissella paramesenteroides (SP216)	101.0	2296.0	8436.0	12221.75	16406.0	1.0	4.75	28.0	4046.5	11022.0	1.0	18.25	28.0	66.25	169.0	1.0	8.0	14.0	54.0	99.0	1.0	1.0	1.0	1.0	15.0	1.0	1.0	1.0	1.0	1.0
Akkermansia muciniphila (SP217)	1.0	1.0	4.5	8.75	13.0	1.0	1.0	1.0	5.5	4190.0	1.0	1.0	1.0	1.5	3.0	6.0	17.0	17.0	86.0	523.0	1.0	1.0	16.0	27.0	310.0	1.0	2.5	35.0	219.0	275.0
Pantoea conspicua (SP236)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	464.0
Staphylococcus ureilyticus (SP274)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	57.0	60.0	125.0	126.0	128.0	1.0	1.0	1.0	2.5	2664.0	1.0	1.0	9.5	21.0	54.0
Lactobacillus johnsonii (SP287)	18.0	3290.25	6013.0	7700.0	17713.0	1.0	936.75	4372.0	11647.25	22478.0	1.0	1.0	6.5	37.5	114.0	5009.0	10428.0	11009.0	17790.0	21511.0	1.0	11.5	106.5	762.25	26282.0	1.0	7.25	29.5	891.75	1446.0
Mammaliicoccus sciuri (SP307)	1.0	1.0	1.0	1.0	4.0	1.0	1.0	45.5	295.5	2811.0	1.0	1.0	11.0	26.5	43.0	1.0	1.0	1.0	1.0	6855.0	1.0	1.0	1.0	1.0	11.0	1.0	1.0	1.0	7.0	161.0
Corynebacterium tuberculostearicum (SP313)	1.0	1.75	4.5	8.75	15.0	1.0	1.0	1.0	1.0	7.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	16.0	18.0	22.0	1.0	1.0	1.0	1.0	1.0	1.0	1.75	6.0	14.75	53.0
Pantoea brenneri (SP319)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	530.0
Staphylococcus capitis (SP35)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	88.75	2306.0	1.0	1.0	1.0	1.0	1.0
Dubosiella newyorkensis (SP368)	1.0	8.0	11.5	40.5	106.0	1.0	1.0	1.0	1.0	318.0	1.0	1.0	1.0	6.5	23.0	22.0	126.0	197.0	221.0	3181.0	1.0	1.0	1.0	2.5	13.0	1.0	1.0	1.0	56.5	788.0
Enterobacter mori (SP370)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	351.25	1402.0	1.0	1.0	1.0	1.0	657.0	1.0	1.0	30.5	3057.25	17890.0	1.0	49.5	1387.0	7828.25	13367.0
Romboutsia timonensis (SP374)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	7.0	1497.0	1.0	1.0	1.0	1.0	1.0	37.0	46.0	91.0	142.0	545.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Atopostipes sp._MOT-201 (SP385)	1.0	1.0	1.0	1.0	6.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	78.0	137.0	169.0	570.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Mixta calida (SP396)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	14326.0	1.0	1.0	1.0	20.25	78.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1663.75	23639.0	1.0	5.0	1301.5	3195.75	11658.0
Faecalibaculum rodentium (SP95)	1.0	1.25	3.5	15.5	33.0	1.0	1.0	1.0	1.0	6990.0	1.0	1.0	1.0	15.75	60.0	1.0	1.0	5.0	13.0	215.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.0	11.0
Muribaculaceae_[G-2] bacterium_MOT-104_nov_90.802% (SPN135)	9.0	102.75	547.0	2001.5	3627.0	1.0	1.0	1.0	1.0	3074.0	1.0	1.0	1.0	2.0	5.0	35.0	60.0	206.0	464.0	5397.0	1.0	1.0	1.0	1.0	36.0	1.0	1.0	16.5	47.0	1442.0
Sporosarcina siberiensis_nov_97.892% (SPN192)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1294.0
Turicibacter sanguinis_nov_96.262% (SPN221)	74.0	126.25	166.0	1489.75	2231.0	1.0	1.0	1.5	2.75	669.0	1.0	1.0	1.0	1.0	1.0	1.0	8.0	15.0	24.0	71.0	1.0	5.0	10.0	17.0	110.0	1.0	1.0	1.0	15.25	135.0
Weissella paramesenteroides_nov_94.614% (SPN308)	72.0	517.5	640.0	782.75	1395.0	1.0	1.0	15.5	42.75	115.0	1.0	4.75	20.0	99.75	297.0	1.0	1.0	1.0	1.0	4.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Enterococcus faecalis_nov_94.614% (SPN386)	24.0	301.25	556.5	623.5	1288.0	1.0	1.0	10.0	49.0	167.0	1.0	5.5	11.0	28.5	69.0	1.0	1.0	1.0	3.0	3.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Muribaculaceae_[G-2] bacterium_MOT-104_nov_89.810% (SPN392)	1.0	8.75	53.0	201.5	245.0	1.0	1.0	1.0	1.0	669.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	29.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	20.5	75.0
Enterococcus faecalis_nov_97.424% (SPN400)	1.0	1.0	1.0	1.0	4.0	1.0	1.0	1.0	2.5	117.0	1.0	1.0	8.5	18.0	24.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	27.0	1.0	1.0	1.0	1.0	1.0
Enterococcus faecalis_nov_94.626% (SPN424)	17.0	882.25	1126.0	1270.0	1718.0	1.0	28.25	119.5	659.25	1692.0	1.0	1.0	8.0	38.5	109.0	24.0	199.0	557.0	1798.0	2008.0	1.0	1.0	1.5	7.25	12.0	1.0	1.0	2.0	35.25	137.0
Gloeobacter kilaueensis_nov_81.638% (SPN50)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	9.25	34.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Lactobacillus johnsonii_nov_94.626% (SPN97)	8.0	939.75	1068.0	1149.75	1218.0	1.0	13.75	54.0	299.75	1905.0	1.0	1.0	11.5	65.0	194.0	24.0	193.0	546.0	1458.0	1633.0	1.0	1.25	15.0	198.75	3195.0	1.0	1.75	9.5	41.25	118.0
Enterococcus multispecies_spp12_2 (SPP12)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	10.75	12015.0	1.0	1.0	118.5	2477.25	9201.0	1.0	1.0	1.0	4.0	91.0	1.0	14490.25	28431.5	48817.0	72476.0	1.0	1264.0	11049.5	33393.75	40685.0
multigenus multispecies_spp143_4 (SPP143)	25.0	39.5	110.5	7035.75	19517.0	1.0	115.75	799.0	3713.5	21285.0	218.0	4431.5	9020.5	13600.75	17788.0	1.0	502.0	1281.0	4141.0	18806.0	1.0	1.0	1.0	1.0	10427.0	1.0	1.0	1.0	268.0	63713.0
Limosilactobacillus multispecies_spp16_2 (SPP16)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4885.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Enterobacter multispecies_spp22_4 (SPP22)	1.0	1.0	1.0	4.75	8.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	273.0	1089.0	1.0	1.0	1.0	11.0	495.0	1.0	1.0	14.5	3042.5	14084.0	1.0	34.25	1027.5	5743.0	10472.0
Clostridium multispecies_spp28_2 (SPP28)	1.0	1.0	1.0	3.25	5.0	1.0	1.0	6.5	25.5	445.0	1.0	1.0	1.0	5.5	19.0	1.0	1.0	1.0	12.0	128.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Enterococcus multispecies_spp29_5 (SPP29)	1.0	4.0	14.5	18.25	40.0	1.0	1.0	1.0	1.0	3.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Blautia multispecies_spp48_3 (SPP48)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.25	10.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	233.0	1.0	1.0	1.0	5.5	147.0
Enterococcus multispecies_spp57_3 (SPP57)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.5	58.0	1.0	1.0	70.0	139.75	142.0	1.0	1.0	3.0	4.0	5.0	1.0	1.0	169.0	429.5	3989.0	1.0	1.0	275.0	1082.25	2435.0
Staphylococcus multispecies_spp59_3 (SPP59)	1.0	1.0	1.0	24.25	57.0	1.0	1.0	1.0	1.0	9.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	445.75	13313.0	1.0	1.0	1.0	1.0	1.0
Enterobacter multispecies_spp72_2 (SPP72)	1.0	5.5	49.5	3737.75	10850.0	1.0	48.75	417.5	1912.0	11964.0	72.0	2608.5	5497.0	8209.25	10217.0	147.0	176.0	703.0	2329.0	10589.0	1.0	1.0	7.0	1460.75	6039.0	1.0	143.25	1239.5	2554.75	38133.0
multigenus multispecies_spp76_2 (SPP76)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	15.0	57.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.0	1.0	1.0	1.0	1.0	706.0
Staphylococcus multispecies_spp82_2 (SPP82)	10.0	13.0	22.5	43.25	647.0	1.0	1.0	7.5	14.75	101.0	1.0	1.0	8.5	16.5	18.0	347.0	374.0	973.0	1613.0	1685.0	1.0	1.0	1.0	60.25	1944.0	1.0	1.0	2.0	18.0	50.0
Bifidobacterium multispecies_spp96_2 (SPP96)	29.0	51.0	108.5	127.75	149.0	1.0	1.0	1.0	199.0	29702.0	1.0	1.0	7.5	202.5	768.0	223.0	4443.0	7137.0	9612.0	57658.0	1.0	1.0	8.0	57.0	462.0	1.0	18.75	72.0	492.75	7019.0
Rhodoligotrophos multispecies_sppn5_2_nov_78.502% (SPPN5)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	6.0	6.0	9.0	41.0	235.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	19.0