Percentile	0.0	25.0	50.0	75.0	100.0	0.0	25.0	50.0	75.0	100.0
Group	Male Brain Genotype+ SPM+ Treated	Male Brain Genotype+ SPM+ Treated	Male Brain Genotype+ SPM+ Treated	Male Brain Genotype+ SPM+ Treated	Male Brain Genotype+ SPM+ Treated	Male Ligature Genotype+ SPM+ Treated	Male Ligature Genotype+ SPM+ Treated	Male Ligature Genotype+ SPM+ Treated	Male Ligature Genotype+ SPM+ Treated	Male Ligature Genotype+ SPM+ Treated
Porphyromonas gingivalis (SP1)	1430.0	2248.0	3066.0	42122.5	81179.0	1.0	7.5	14.0	20.0	26.0
Enterococcus gallinarum (SP100)	1.0	1.0	1.0	1.0	1.0	6.0	15.0	24.0	662.0	1300.0
Treponema sp. HMT256 (SP101)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.0	9.0
Fusobacterium nucleatum_subsp._vincentii (SP102)	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0	16.0	24.0
Enterobacter cancerogenus (SP103)	1.0	2.0	3.0	241.5	480.0	1.0	120.5	240.0	17582.5	34925.0
Lactobacillus johnsonii (SP110)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	14.5	28.0
Tannerella forsythia (SP112)	1.0	1.0	1.0	541.0	1081.0	1.0	3.0	5.0	6.5	8.0
Fusobacterium nucleatum_subsp._animalis (SP12)	1.0	1.0	1.0	744.0	1487.0	1.0	1.0	1.0	1.0	1.0
Staphylococcus ureilyticus (SP120)	1.0	1.0	1.0	576.5	1152.0	1.0	1.0	1.0	12.0	23.0
Leptotrichia shahii (SP122)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.5	6.0
Selenomonas dianae (SP123)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.0	7.0
Streptococcus mitis (SP128)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	6.0	11.0
Fusobacterium nucleatum (SP13)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	17.0	33.0
Jeotgalicoccus halotolerans (SP131)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2.5	4.0
Phocaeicola sartorii (SP132)	1.0	1.0	1.0	1.0	1.0	6.0	1289.5	2573.0	4062.5	5552.0
Sphingomonas echinoides (SP134)	1.0	1.0	1.0	3716.0	7431.0	1.0	1.0	1.0	1.0	1.0
Alloprevotella tannerae (SP138)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.5	10.0
Muribaculum intestinale (SP140)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0
Citrobacter koseri (SP142)	1.0	1.0	1.0	317.0	633.0	1.0	1.0	1.0	34.0	67.0
Chryseobacterium gambrini (SP143)	1.0	1.0	1.0	245.5	490.0	1.0	1.0	1.0	1.0	1.0
Triticum aestivum (SP146)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	11.0	21.0
Acinetobacter radioresistens (SP148)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	8.0	15.0
Enterobacter hormaechei (SP15)	1.0	1.0	1.0	1063.5	2126.0	1.0	1.0	1.0	10660.5	21320.0
Streptococcus intermedius (SP166)	1.0	1.0	1.0	1.0	1.0	1.0	3.0	5.0	5.0	5.0
Klebsiella pneumoniae (SP17)	2408.0	3117.5	3827.0	28027.0	52227.0	17865.0	79893.5	141922.0	167176.5	192431.0
Streptococcus gordonii (SP171)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.5	10.0
Enterobacter asburiae (SP173)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	6525.0	13049.0
Desulfobulbus sp. HMT041 (SP178)	1.0	1.0	1.0	277.5	554.0	1.0	1.0	1.0	1.0	1.0
Ligilactobacillus murinus (SP18)	1.0	1.0	1.0	1.0	1.0	87.0	1040.0	1993.0	19021.5	36050.0
Ottowia sp. HMT894 (SP185)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.5	6.0
Bacteroides caccae (SP195)	1.0	1.0	1.0	1.0	1.0	1.0	24.5	48.0	824.5	1601.0
Saccharibacteria_(TM7)_[G-2] bacterium HMT350 (SP196)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.0	5.0
Leptotrichia trevisanii (SP198)	1.0	1.0	1.0	886.5	1772.0	1.0	1.0	1.0	1.0	1.0
Kosakonia sacchari (SP20)	1.0	1.0	1.0	619.5	1238.0	1.0	1.0	1.0	1.0	1.0
Bergeyella sp. HMT900 (SP203)	1.0	1.0	1.0	752.0	1503.0	1.0	1.0	1.0	1.0	1.0
Actinomyces sp. HMT897 (SP208)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.0	5.0
Leptotrichia buccalis (SP213)	1.0	1.0	1.0	1506.0	3011.0	1.0	1.0	1.0	1.0	1.0
Bacteroidaceae_[G-1] bacterium HMT272 (SP214)	1.0	1.0	1.0	1307.0	2613.0	1.0	1.0	1.0	1.0	1.0
Prevotella pleuritidis (SP215)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	6.0	11.0
Streptococcus oralis (SP223)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2.5	4.0
Actinomyces israelii (SP228)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.0	5.0
Streptococcus australis (SP23)	1.0	1.0	1.0	794.0	1587.0	1.0	1.0	1.0	1.0	1.0
Treponema amylovorum (SP231)	1.0	1.0	1.0	871.5	1742.0	1.0	1.0	1.0	1.0	1.0
Acidovorax defluvii (SP234)	1.0	1.0	1.0	626.5	1252.0	1.0	1.0	1.0	1.0	1.0
Bacteroidetes_[G-5] bacterium HMT511 (SP236)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2.5	4.0
Fusobacterium periodonticum (SP239)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	11.0	21.0
Alloprevotella sp. HMT473 (SP242)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.0	7.0
Selenomonas artemidis (SP27)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	6.0	11.0
Enterobacter cloacae (SP28)	1.0	1.0	1.0	805.5	1610.0	1.0	4956.5	9912.0	40928.5	71945.0
Bacteroidetes_[G-3] bacterium HMT280 (SP31)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.0	7.0
Filifactor alocis (SP32)	1.0	1.0	1.0	1034.0	2067.0	1.0	1.0	1.0	1.0	1.0
Veillonella parvula (SP33)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.0	7.0
Bacillus subtilis (SP35)	1.0	1.0	1.0	34.0	67.0	1.0	1.0	1.0	1.0	1.0
Enterococcus faecalis (SP37)	1.0	1.0	1.0	1.0	1.0	1194.0	5148.0	9102.0	27838.5	46575.0
Faecalibaculum rodentium (SP39)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2812.5	5624.0
Cutibacterium acnes (SP41)	1.0	1.0	1.0	1674.0	3347.0	1.0	4.5	8.0	19.5	31.0
Acinetobacter johnsonii (SP42)	1.0	1.0	1.0	889.0	1777.0	1.0	1.0	1.0	1.0	1.0
Bacillus halotolerans (SP53)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0
Fretibacterium sp. HMT360 (SP55)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0
Actinidia eriantha (SP64)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.0	7.0
Limosilactobacillus reuteri (SP65)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	13.5	26.0
Treponema sp. HMT237 (SP66)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2.5	4.0
Neisseriaceae_[G-1] bacterium_MOT-031 (SP69)	1.0	1.0	1.0	1.0	1.0	1.0	6.0	11.0	2083.0	4155.0
Streptococcus thoraltensis (SP70)	1.0	1.0	1.0	1.0	1.0	8.0	13540.0	27072.0	28086.5	29101.0
Streptococcus danieliae (SP73)	1.0	1.0	1.0	1.0	1.0	103.0	245.0	387.0	536.5	686.0
Prevotella sp. HMT472 (SP75)	1.0	1.0	1.0	405.5	810.0	1.0	1.0	1.0	1.0	1.0
Proteus mirabilis (SP8)	1.0	869.5	1738.0	2093.5	2449.0	1.0	1.0	1.0	9.0	17.0
Aggregatibacter sp. HMT512 (SP80)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0
Pelomonas saccharophila (SP81)	1.0	1.0	1.0	14098.5	28196.0	1.0	1.0	1.0	1.0	1.0
Corynebacterium godavarianum (SP90)	1.0	1.0	1.0	33054.5	66108.0	1.0	1.0	1.0	1.0	1.0
Treponema sp. HMT230 (SP93)	1.0	1.0	1.0	592.0	1183.0	1.0	1.0	1.0	1.0	1.0
Corynebacterium singulare (SP98)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0
Duncaniella freteri_nov_89.775% (SPN10)	1.0	1.0	1.0	1388.0	2775.0	1.0	1.0	1.0	1.0	1.0
Oscillospiraceae_[G-4] bacterium_MOT-151_nov_92.562% (SPN100)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2.5	4.0
Sphingomonas psychrolutea_nov_91.667% (SPN102)	1.0	1.0	1.0	2.5	4.0	1.0	1.0	1.0	1.0	1.0
Desulfovibrio fairfieldensis_nov_88.934% (SPN11)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.0	7.0
Thermoanaerobaculum aquaticum_nov_78.020% (SPN112)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2.0	3.0
Enterobacter cloacae_nov_89.357% (SPN113)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2.0	3.0
Prevotella shahii_nov_87.602% (SPN118)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	9.5	18.0
Duncaniella freteri_nov_89.113% (SPN120)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	8.0	15.0
Lawsonibacter asaccharolyticus_nov_91.116% (SPN125)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	6.5	12.0
Sphaerobacter thermophilus_nov_82.265% (SPN126)	1.0	1.0	1.0	8567.5	17134.0	1.0	1.0	1.0	1.0	1.0
Duncaniella freteri_nov_89.718% (SPN127)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	7.0	13.0
Pyrinomonas methylaliphatogenes_nov_96.809% (SPN129)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.0	9.0
Muribaculaceae_[G-1] bacterium_MOT-129_nov_85.887% (SPN131)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	9.5	18.0
Duncaniella freteri_nov_90.612% (SPN132)	1.0	1.0	1.0	389.0	777.0	1.0	1.0	1.0	4.0	7.0
Alloprevotella sp. HMT473 nov_89.366% (SPN134)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	11.5	22.0
Lachnospiraceae_[G-6] bacterium_MOT-171_nov_95.388% (SPN16)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	13.0	25.0
Saccharibacteria_(TM7)_[G-3] bacterium HMT351 nov_95.400% (SPN17)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0
Lawsonibacter asaccharolyticus_nov_91.116% (SPN23)	1.0	1.0	1.0	772.5	1544.0	1.0	1.0	1.0	1.0	1.0
Parasutterella excrementihominis_nov_94.578% (SPN24)	1.0	1.0	1.0	1.0	1.0	1.0	28.5	56.0	66.5	77.0
Alistipes senegalensis_nov_92.197% (SPN26)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	10.0	19.0
Kineothrix alysoides_nov_87.083% (SPN30)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	9.0	17.0
Muribaculaceae_[G-1] bacterium_MOT-129_nov_87.602% (SPN34)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.0	9.0
Marvinbryantia formatexigens_nov_90.578% (SPN36)	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0	8.5	9.0
Oscillospiraceae_[G-2] bacterium_MOT-149_nov_95.228% (SPN48)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	6.0	11.0
Solirubrobacter ginsenosidimutans_nov_89.431% (SPN49)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.5	10.0
Muribaculaceae_[G-1] bacterium_MOT-129_nov_83.636% (SPN5)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	8.0	15.0
Roseburia intestinalis_nov_90.021% (SPN50)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.5	10.0
Culturomica massiliensis_nov_89.613% (SPN51)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0
Streptococcus azizii_nov_95.171% (SPN52)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	26.0	51.0
Fusicatenibacter saccharivorans_nov_90.316% (SPN54)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.0	9.0
Falsiroseomonas bella_nov_95.172% (SPN57)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.0	9.0
Lachnospiraceae_[G-7] bacterium_MOT-172_nov_92.133% (SPN64)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0
Lachnospiraceae_[G-14] bacterium_MOT-183_nov_97.854% (SPN70)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.5	8.0
Duncaniella freteri_nov_93.699% (SPN72)	1.0	1.0	1.0	208.0	415.0	1.0	1.0	1.0	9.5	18.0
Duncaniella freteri_nov_93.509% (SPN79)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	6.0	11.0
Muribaculaceae_[G-1] bacterium_MOT-129_nov_87.045% (SPN8)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	7.5	14.0
Lachnospiraceae_[G-11] bacterium_MOT-176_nov_93.279% (SPN84)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.0	5.0
Lacrimispora xylanolytica_nov_94.363% (SPN85)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.0	5.0
Saccharibacteria_(TM7)_[G-3] bacterium HMT351 nov_94.212% (SPN88)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.0	5.0
Peptostreptococcaceae_[XI][G-5] bacterium HMT493 nov_90.000% (SPN93)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2.5	4.0
Lachnospiraceae_[G-14] bacterium_MOT-182_nov_90.192% (SPN94)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2.5	4.0
Bacillus multispecies_spp1_6 (SPP1)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	2.0	3.0
Veillonella multispecies_spp10_2 (SPP10)	1.0	1.0	1.0	1131.0	2261.0	1.0	1.0	1.0	1.0	1.0
Staphylococcus multispecies_spp12_3 (SPP12)	1.0	1.0	1.0	1.0	1.0	455.0	1118.0	1781.0	3857.0	5933.0
Staphylococcus multispecies_spp13_2 (SPP13)	1.0	1.0	1.0	440.5	880.0	1.0	1.0	1.0	19.0	37.0
Staphylococcus multispecies_spp15_2 (SPP15)	1.0	1.0	1.0	1.0	1.0	20.0	23.0	26.0	49.5	73.0
Fusobacterium multispecies_spp4_2 (SPP4)	1.0	1.0	1.0	707.0	1413.0	1.0	1.0	1.0	1.0	1.0
Lacrimispora multispecies_sppn2_2_nov_92.872% (SPPN2)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	9.5	18.0
multigenus multispecies_sppn4_2_nov_93.290% (SPPN4)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	7.0	13.0