Percentile	0.0	25.0	50.0	75.0	100.0	0.0	25.0	50.0	75.0	100.0	0.0	25.0	50.0	75.0	100.0
Group	KLK4KO	KLK4KO	KLK4KO	KLK4KO	KLK4KO	WT-F17722	WT-F17722	WT-F17722	WT-F17722	WT-F17722	WT-F18971	WT-F18971	WT-F18971	WT-F18971	WT-F18971
Porphyromonas sp._MOT-131 (SP103)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	26.0	96.0	1401.0	8490.0	25274.0
Pediococcus pentosaceus (SP104)	78.0	91.0	113.0	119.0	1787.0	1.0	1.0	1.0	1.0	1.0	185.0	191.0	211.0	1078.0	3157.0
Streptococcus acidominimus (SP106)	23.0	48.0	130.0	634.0	5411.0	1.0	1.0	1.0	1.0	1.0	65.0	255.0	283.0	693.0	2412.0
Streptococcus danieliae (SP11)	53011.0	58996.0	70225.0	85991.0	116807.0	1.0	1.0	1.0	1.0	1.0	44518.0	68106.0	68731.0	110159.0	148230.0
Eubacteriales_[G-4] bacterium_MOT-164 (SP110)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	26.0	367.0	1.0	1.0	1.0	1.0	5.0
Enterococcus faecalis (SP114)	1.0	1.0	5.0	179.0	333.0	1.0	1.0	42.0	86.0	91.0	1.0	1.0	1.0	1.0	1.0
Corynebacterium stationis (SP12)	21.0	25.0	27.0	50.0	82.0	298.0	511.0	1389.0	2531.0	2849.0	1.0	1.0	1.0	1.0	125.0
Mammaliicoccus lentus (SP121)	97.0	112.0	134.0	241.0	553.0	7827.0	8223.0	9855.0	14090.0	14370.0	1.0	1.0	1.0	7.0	39.0
Bifidobacterium pseudolongum (SP129)	1.0	1.0	1.0	20.0	69.0	1.0	16.0	480.0	1855.0	4454.0	1.0	12.0	17.0	26.0	105.0
Mollicutes_[G-1] bacterium_MOT-186 (SP133)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	19.0	487.0	1.0	1.0	1.0	1.0	1.0
Lactococcus lactis (SP135)	1.0	1.0	1.0	4.0	36.0	1.0	1.0	1.0	1.0	1.0	8.0	10.0	67.0	149.0	294.0
Lactobacillus johnsonii (SP138)	1.0	1.0	5.0	7.0	77.0	1.0	70.0	229.0	386.0	585.0	15.0	19.0	28.0	246.0	283.0
Streptococcus thoraltensis (SP14)	6.0	21.0	33.0	34.0	35.0	1.0	1.0	1.0	1.0	1.0	11.0	13.0	44.0	124.0	830.0
Stenotrophomonas [Pseudomonas] hibiscicola (SP149)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.0	1.0	1.0	1.0	1.0	1.0
Staphylococcus ureilyticus (SP15)	1.0	24.0	38.0	60.0	385.0	4255.0	5003.0	6316.0	6419.0	8797.0	1.0	1.0	1.0	10.0	33.0
Weissella cibaria (SP168)	1.0	1.0	19.0	28.0	32.0	1.0	1.0	1.0	1.0	1.0	13.0	52.0	105.0	180.0	741.0
Staphylococcus saprophyticus (SP17)	1.0	1.0	1.0	1.0	1.0	76.0	85.0	159.0	424.0	664.0	1.0	1.0	1.0	1.0	1.0
Triticum aestivum (SP2)	1.0	1.0	1.0	1.0	46.0	1.0	1.0	26.0	107.0	2781.0	1.0	36.0	56.0	173.0	1006.0
Muribacter sp._MOT-143 (SP22)	49156.0	51650.0	60117.0	63975.0	89852.0	1.0	1.0	1.0	1.0	1.0	6908.0	28491.0	32872.0	59545.0	75021.0
Rodentibacter pneumotropicus (SP23)	835.0	1381.0	3012.0	10594.0	12848.0	1.0	1.0	1.0	1.0	1.0	414.0	2234.0	2604.0	4605.0	45775.0
Streptococcus thermophilus (SP25)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	39.0	1.0	1.0	1.0	8.0	14.0
Enterococcus gallinarum (SP3)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.0	10.0	70.0	1.0	1.0	1.0	1.0	1.0
Limosilactobacillus reuteri (SP33)	1.0	1.0	1.0	1.0	39.0	1.0	22.0	32.0	55.0	249.0	1.0	14.0	23.0	45.0	134.0
Staphylococcus equorum (SP34)	1.0	1.0	1.0	1.0	13.0	4105.0	4439.0	6752.0	9924.0	12130.0	1.0	1.0	1.0	1.0	1.0
Dubosiella newyorkensis (SP38)	1.0	1.0	1.0	1.0	1.0	1.0	18.0	153.0	557.0	5197.0	1.0	1.0	1.0	1.0	1.0
Atopostipes sp._MOT-201 (SP41)	1.0	14.0	33.0	33.0	60.0	43.0	99.0	146.0	196.0	229.0	1.0	1.0	1.0	1.0	1.0
Ligilactobacillus animalis (SP42)	1.0	1.0	1.0	1.0	1.0	44588.0	65244.0	78348.0	81698.0	107864.0	1.0	1.0	1.0	1.0	1.0
Lachnospiraceae_[G-14] bacterium_MOT-185 (SP43)	1.0	1.0	1.0	1.0	4.0	1.0	1.0	1.0	9.0	1079.0	1.0	1.0	1.0	1.0	1.0
Ligilactobacillus murinus (SP44)	9.0	23.0	30.0	186.0	1326.0	1.0	1.0	17.0	22.0	182.0	9.0	156.0	226.0	363.0	902.0
Eubacteriales_[G-2] bacterium_MOT-162 (SP46)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	9.0	488.0	1.0	1.0	1.0	1.0	1.0
Corynebacterium mastitidis (SP48)	88.0	93.0	430.0	1841.0	2572.0	1.0	1.0	1.0	1.0	1.0	42.0	116.0	269.0	294.0	463.0
Cutibacterium acnes (SP50)	1.0	1.0	6.0	7.0	10.0	1.0	1.0	6.0	8.0	11.0	1.0	4.0	20.0	20.0	30.0
Clostridium disporicum (SP52)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	633.0	1.0	1.0	1.0	1.0	1.0
Stenotrophomonas maltophilia (SP54)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	21.0	25.0	1.0	1.0	1.0	1.0	15.0
Lachnospiraceae_[G-11] bacterium_MOT-177 (SP57)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	6.0	11.0	374.0	1.0	1.0	1.0	1.0	1.0
Pseudomonas helleri (SP64)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	4.0	1.0	1.0	1.0	1.0	12.0
Lacticaseibacillus rhamnosus (SP65)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	16.0	29.0	30.0	1.0	1.0	1.0	1.0	6.0
Jeotgalicoccus halotolerans (SP69)	38.0	61.0	69.0	82.0	1002.0	3165.0	4234.0	4996.0	7538.0	10485.0	1.0	1.0	6.0	12.0	78.0
Levilactobacillus brevis (SP71)	22.0	34.0	38.0	54.0	674.0	1.0	1.0	1.0	1.0	1.0	8.0	12.0	36.0	166.0	888.0
Gemella sp._MOT-033 (SP72)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	27.0	31.0	33.0	300.0	955.0
Corynebacterium ammoniagenes (SP73)	1.0	1.0	1.0	1.0	1.0	123.0	372.0	1294.0	1309.0	1424.0	1.0	1.0	1.0	1.0	1.0
Leptothrix sp. HMT025 (SP77)	1.0	1.0	1.0	4.0	5.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	9.0	16.0
Weissella paramesenteroides (SP8)	17.0	34.0	46.0	116.0	794.0	1.0	1.0	1.0	1.0	1.0	77.0	511.0	1329.0	1348.0	2520.0
Carnobacteriaceae_[G-1] bacterium_MOT-197 (SP87)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	50.0	102.0	690.0	5082.0	12252.0
Rothia nasimurium (SP90)	1.0	8.0	8.0	11.0	76.0	1.0	1.0	1.0	1.0	1.0	1.0	10.0	48.0	131.0	419.0
Ralstonia sp. HMT406 (SP96)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.0	6.0	29.0	1.0	1.0	1.0	1.0	7.0
Actinidia eriantha (SP97)	1.0	1.0	1.0	16.0	17.0	1.0	1.0	1.0	10.0	82.0	6.0	10.0	20.0	30.0	579.0
Akkermansia muciniphila (SP99)	1.0	1.0	1.0	1.0	1.0	1.0	84.0	480.0	494.0	2694.0	1.0	1.0	1.0	1.0	1.0
Muribaculaceae_[G-1] bacterium_MOT-129_nov_88.105% (SPN109)	1.0	1.0	1.0	1.0	1.0	1.0	17.0	282.0	507.0	2358.0	1.0	1.0	1.0	1.0	1.0
Duncaniella freteri_nov_93.293% (SPN110)	1.0	1.0	1.0	1.0	1.0	1.0	36.0	426.0	806.0	4480.0	1.0	1.0	1.0	1.0	1.0
Turicibacter sanguinis_nov_95.923% (SPN122)	1.0	1.0	1.0	1.0	1.0	1.0	22.0	32.0	150.0	1349.0	1.0	1.0	1.0	1.0	1.0
Enterococcus faecalis_nov_95.825% (SPN151)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	9.0	32.0	1.0	1.0	1.0	1.0	1.0
Fusobacterium varium_nov_96.696% (SPN159)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	15.0	17.0	1.0	1.0	1.0	1.0	1.0
Muribaculaceae_[G-2] bacterium_MOT-104_nov_88.867% (SPN188)	1.0	1.0	1.0	1.0	1.0	1.0	121.0	673.0	1150.0	7140.0	1.0	1.0	1.0	1.0	1.0
Oribacterium parvum_nov_89.770% (SPN21)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	449.0	1.0	1.0	1.0	1.0	1.0
Duncaniella freteri_nov_89.775% (SPN226)	1.0	1.0	1.0	1.0	1.0	1.0	15.0	91.0	216.0	1824.0	1.0	1.0	1.0	1.0	1.0
Alistipes senegalensis_nov_93.443% (SPN272)	1.0	1.0	1.0	1.0	8.0	1.0	1.0	27.0	77.0	869.0	1.0	1.0	1.0	1.0	1.0
Erysipelotrichaceae_[G-1] bacterium_MOT-189_nov_88.798% (SPN276)	10.0	13.0	16.0	22.0	180.0	1.0	1.0	1.0	1.0	1.0	33.0	44.0	114.0	188.0	283.0
Peptococcus sp. HMT168 nov_84.866% (SPN283)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	35.0	852.0	1.0	1.0	1.0	1.0	1.0
Duncaniella freteri_nov_89.718% (SPN286)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	79.0	210.0	442.0	1.0	1.0	1.0	1.0	1.0
Fusicatenibacter saccharivorans_nov_90.526% (SPN29)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	448.0	1.0	1.0	1.0	1.0	1.0
Oscillospiraceae_[G-6] bacterium_MOT-153_nov_91.631% (SPN293)	1.0	1.0	1.0	1.0	1.0	1.0	17.0	41.0	81.0	484.0	1.0	1.0	1.0	1.0	1.0
Muribaculaceae_[G-2] bacterium_MOT-104_nov_89.000% (SPN302)	1.0	1.0	1.0	1.0	7.0	1.0	1.0	52.0	126.0	432.0	1.0	1.0	1.0	1.0	1.0
Lachnospiraceae_[G-14] bacterium_MOT-185_nov_92.719% (SPN311)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	35.0	168.0	1.0	1.0	1.0	1.0	1.0
Muribaculaceae_[G-2] bacterium_MOT-104_nov_88.423% (SPN47)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	29.0	377.0	1.0	1.0	1.0	1.0	1.0
Muribaculaceae_[G-1] bacterium_MOT-129_nov_85.887% (SPN54)	1.0	1.0	1.0	1.0	32.0	1.0	34.0	42.0	43.0	191.0	1.0	1.0	1.0	9.0	39.0
Duncaniella freteri_nov_88.934% (SPN66)	1.0	1.0	1.0	1.0	1.0	1.0	17.0	146.0	234.0	3323.0	1.0	1.0	1.0	1.0	1.0
Duncaniella freteri_nov_93.699% (SPN72)	1.0	1.0	1.0	1.0	1.0	16.0	47.0	758.0	1261.0	8933.0	1.0	1.0	1.0	1.0	1.0
Latilactobacillus multispecies_spp10_2 (SPP10)	9.0	24.0	30.0	38.0	405.0	1.0	1.0	1.0	1.0	1.0	21.0	56.0	71.0	259.0	544.0
Sphingomonas multispecies_spp11_2 (SPP11)	11.0	15.0	23.0	36.0	37.0	16.0	38.0	49.0	130.0	231.0	10.0	23.0	54.0	63.0	72.0
Staphylococcus multispecies_spp9_2 (SPP9)	175.0	234.0	748.0	2127.0	3028.0	678.0	1407.0	2518.0	3993.0	6807.0	30.0	71.0	78.0	196.0	431.0