Percentile	0.0	25.0	50.0	75.0	100.0	0.0	25.0	50.0	75.0	100.0
Group	12 Weeks.A.Plaque 1	12 Weeks.A.Plaque 1	12 Weeks.A.Plaque 1	12 Weeks.A.Plaque 1	12 Weeks.A.Plaque 1	24 Weeks.A.Plaque 1	24 Weeks.A.Plaque 1	24 Weeks.A.Plaque 1	24 Weeks.A.Plaque 1	24 Weeks.A.Plaque 1
Streptococcus gordonii (SP1)	1.0	1.0	85.0	200.25	952.0	1.0	1.0	39.0	126.75	547.0
Lactobacillus vaginalis (SP11)	1.0	1.0	1.0	1.0	198.0	1.0	1.0	1.0	1.0	38.0
Actinomyces sp. HMT170 (SP13)	1.0	1.0	1.0	1.0	342.0	1.0	1.0	1.0	1.0	225.0
Fretibacterium fastidiosum (SP14)	1.0	1.0	1.0	61.0	214.0	1.0	1.0	1.0	1.0	167.0
Selenomonas dianae (SP15)	1.0	1.0	1.0	1.0	60.0	1.0	1.0	1.0	1.0	168.0
Colibacter massiliensis (SP17)	1.0	1.0	1.0	1.0	194.0	1.0	1.0	1.0	1.0	64.0
Streptococcus intermedius (SP18)	1.0	1.0	14.0	131.0	1742.0	1.0	1.0	18.0	116.0	1513.0
Saccharibacteria_(TM7)_[G-5] bacterium HMT356 (SP19)	1.0	1.0	1.0	50.0	537.0	1.0	1.0	1.0	78.75	2258.0
Fusobacterium sp. HMT204 (SP2)	1.0	1.0	1.0	1.0	90.0	1.0	1.0	1.0	1.0	138.0
Fusobacterium nucleatum (SP20)	1.0	1.0	1.0	54.5	489.0	1.0	1.0	1.0	70.25	228.0
Selenomonas infelix (SP21)	1.0	1.0	1.0	1.0	132.0	1.0	1.0	1.0	1.0	207.0
Peptococcus sp._Oral_Taxon_167 (SP22)	1.0	1.0	1.0	1.0	81.0	1.0	1.0	1.0	1.0	73.0
Dialister invisus (SP25)	1.0	1.0	28.5	215.0	509.0	1.0	1.0	41.5	89.5	200.0
Veillonella atypica (SP27)	1.0	1.0	1.0	1.0	113.0	1.0	1.0	1.0	1.0	124.0
Selenomonas noxia (SP28)	1.0	1.0	1.0	55.25	348.0	1.0	1.0	1.0	1.0	132.0
Saccharibacteria_(TM7)_[G-1] bacterium HMT957 (SP29)	1.0	1.0	1.0	19.75	129.0	1.0	1.0	1.0	1.0	109.0
Streptococcus anginosus (SP3)	1.0	1.0	1.0	73.0	617.0	1.0	1.0	1.0	85.25	701.0
Streptococcus mutans (SP31)	1.0	1.0	1.0	9.0	2442.0	1.0	1.0	1.0	73.75	3634.0
Saccharibacteria_(TM7)_[G-1] bacterium HMT347 (SP32)	1.0	1.0	1.0	1.0	472.0	1.0	1.0	1.0	1.0	103.0
Megasphaera micronuciformis (SP33)	1.0	1.0	1.0	1.0	179.0	1.0	1.0	1.0	1.0	71.0
Actinomyces sp. HMT171 (SP34)	1.0	1.0	1.0	1.0	201.0	1.0	1.0	1.0	1.0	847.0
Selenomonas artemidis (SP36)	1.0	1.0	1.0	1.0	218.0	1.0	1.0	1.0	1.0	82.0
Actinomyces massiliensis (SP37)	1.0	1.0	1.0	12.0	1649.0	1.0	1.0	1.0	1.0	339.0
Actinomyces gerencseriae (SP38)	1.0	1.0	1.0	25.0	2203.0	1.0	1.0	1.0	1.0	130.0
Fusobacterium periodonticum (SP4)	1.0	1.0	1.0	1.0	579.0	1.0	1.0	1.0	1.0	346.0
Saccharibacteria_(TM7)_[G-1] bacterium HMT349 (SP41)	1.0	1.0	1.0	25.75	203.0	1.0	1.0	1.0	72.75	372.0
Actinomyces sp._Oral_Taxon_171 (SP47)	1.0	1.0	1.0	1.0	463.0	1.0	1.0	1.0	1.0	375.0
Saccharibacteria_(TM7)_[G-1] bacterium HMT346 (SP48)	1.0	1.0	1.0	65.25	194.0	1.0	1.0	1.0	1.0	197.0
Fusobacterium nucleatum_ss_polymorphum (SP5)	1.0	1.0	1.0	118.0	609.0	1.0	1.0	1.0	29.0	482.0
Lactobacillus gasseri (SP52)	1.0	1.0	1.0	1.0	44.0	1.0	1.0	1.0	1.0	1.0
Anaeroglobus geminatus (SP53)	1.0	1.0	1.0	1.0	226.0	1.0	1.0	1.0	1.0	210.0
Lactobacillus fermentum (SP6)	1.0	1.0	1.0	1.0	161.0	1.0	1.0	1.0	1.0	17.0
Actinomyces naeslundii (SP60)	1.0	1.0	1.0	1.0	520.0	1.0	1.0	1.0	1.0	324.0
Streptococcus sp._str._2136FAA (SP61)	1.0	1.0	1.0	1.0	399.0	1.0	1.0	1.0	43.75	1114.0
Streptococcus constellatus (SP64)	1.0	1.0	1.0	1.0	178.0	1.0	1.0	1.0	1.0	65.0
Dialister pneumosintes (SP67)	1.0	1.0	1.0	64.0	129.0	1.0	1.0	1.0	1.0	109.0
Veillonella parvula (SP7)	1.0	230.5	433.5	674.5	2517.0	1.0	153.25	288.5	545.75	1354.0
Streptococcus pyogenes_nov_91.53% (SPN110)	1.0	1.0	1.0	94.75	1131.0	1.0	1.0	1.0	32.0	597.0
Geosporobacter subterraneus_nov_88.43% (SPN123)	1.0	1.0	1.0	1.0	108.0	1.0	1.0	1.0	1.0	105.0
Anaerocolumna xylanovorans_nov_86.91% (SPN128)	1.0	1.0	1.0	1.0	130.0	1.0	1.0	1.0	1.0	231.0
Candidatus_Amoebophilus asiaticus_nov_80.21% (SPN146)	1.0	1.0	1.0	1.0	179.0	1.0	1.0	1.0	1.0	69.0
Fusobacterium hwasookii_nov_87.47% (SPN152)	1.0	1.0	7.5	117.75	1297.0	1.0	1.0	1.0	65.5	492.0
Thermotalea metallivorans_nov_88.34% (SPN156)	1.0	1.0	1.0	1.0	111.0	1.0	1.0	1.0	1.0	155.0
Bacteroides capillosus_nov_81.31% (SPN163)	1.0	1.0	1.0	1.0	171.0	1.0	1.0	1.0	1.0	83.0
Streptococcus rifensis_nov_90.02% (SPN175)	1.0	1.0	1.0	1.0	37.0	1.0	1.0	1.0	1.0	271.0
Fusobacterium hwasookii_nov_88.45% (SPN180)	1.0	1.0	1.0	1.0	314.0	1.0	1.0	1.0	1.0	279.0
Winogradskyella eckloniae_nov_83.62% (SPN202)	1.0	1.0	1.0	1.0	136.0	1.0	1.0	1.0	1.0	101.0
Vagococcus lutrae_nov_87.66% (SPN209)	1.0	1.0	103.0	245.75	431.0	1.0	1.0	44.0	87.75	312.0
Corynebacterium riegelii_nov_90.36% (SPN210)	1.0	1.0	1.0	1.0	280.0	1.0	1.0	1.0	1.0	141.0
Fusobacterium periodonticum_nov_86.34% (SPN212)	1.0	1.0	1.0	1.0	63.0	1.0	1.0	1.0	1.0	178.0
Arenibacter algicola_nov_84.04% (SPN213)	1.0	1.0	1.0	1.0	94.0	1.0	1.0	1.0	1.0	70.0
Fusobacterium sp. HMT248 nov_86.74% (SPN215)	1.0	1.0	1.0	1.0	151.0	1.0	1.0	1.0	1.0	269.0
Alistipes indistinctus_nov_85.15% (SPN216)	1.0	1.0	1.0	1.0	451.0	1.0	1.0	1.0	1.0	203.0
Alicyclobacillus acidiphilus_nov_83.26% (SPN217)	1.0	1.0	1.0	3.0	153.0	1.0	1.0	1.0	1.0	175.0
Bowdeniella nasicola_nov_86.78% (SPN218)	1.0	1.0	1.0	76.25	828.0	1.0	1.0	1.0	63.25	174.0
Thermotalea metallivorans_nov_87.32% (SPN219)	1.0	1.0	1.0	1.0	125.0	1.0	1.0	1.0	1.0	75.0
Tessaracoccus lapidicaptus_nov_87.1% (SPN22)	1.0	1.0	1.0	1.0	203.0	1.0	1.0	1.0	1.0	108.0
Sneathia sanguinegens_nov_85.23% (SPN220)	1.0	1.0	1.0	1.0	443.0	1.0	1.0	1.0	1.0	80.0
Isoptericola cucumis_nov_88.91% (SPN221)	1.0	1.0	1.0	1.0	82.0	1.0	1.0	1.0	1.0	100.0
Clostridium acetobutylicum_nov_85.54% (SPN222)	1.0	1.0	1.0	1.0	133.0	1.0	1.0	1.0	1.0	98.0
Nonomuraea lactucae_nov_85.43% (SPN223)	1.0	1.0	1.0	1.0	391.0	1.0	1.0	1.0	1.0	166.0
Xylanibacterium ulmi_nov_87.14% (SPN224)	1.0	1.0	1.0	1.0	124.0	1.0	1.0	1.0	1.0	205.0
Streptococcus rifensis_nov_90.82% (SPN226)	1.0	1.0	6.0	133.0	3262.0	1.0	1.0	1.0	10.75	563.0
Enterococcus sulfureus_nov_88.64% (SPN227)	1.0	1.0	1.0	1.0	36.0	1.0	1.0	1.0	1.0	97.0
Chryseobacterium taeanense_nov_85.32% (SPN228)	1.0	1.0	1.0	1.0	107.0	1.0	1.0	1.0	1.0	102.0
Arenibacter algicola_nov_85.44% (SPN229)	1.0	1.0	1.0	1.0	123.0	1.0	1.0	1.0	1.0	183.0
Bacteroidetes_[G] sp._Oral_Taxon_B68_nov_82.03% (SPN235)	1.0	1.0	43.5	130.0	306.0	1.0	1.0	59.5	114.25	484.0
Campylobacter curvus_nov_91.68% (SPN242)	1.0	43.75	96.0	175.0	385.0	1.0	1.0	61.0	145.25	328.0
Coprococcus eutactus_nov_89.48% (SPN246)	1.0	1.0	1.0	14.25	97.0	1.0	1.0	1.0	1.0	72.0
Streptococcus rifensis_nov_90.65% (SPN249)	1.0	1.0	34.0	140.5	866.0	1.0	1.0	1.0	29.75	477.0
Streptococcus pyogenes_nov_89.52% (SPN254)	1.0	1.0	1.0	68.25	939.0	1.0	1.0	1.0	15.0	2241.0
Corynebacterium terpenotabidum_nov_92.31% (SPN261)	1.0	1.0	1.0	1.0	5722.0	1.0	1.0	1.0	34.5	1007.0
Geosporobacter subterraneus_nov_88.04% (SPN273)	1.0	1.0	43.0	136.0	675.0	1.0	1.0	1.0	57.0	414.0
Streptococcus pyogenes_nov_89.52% (SPN293)	1.0	72.5	210.0	549.5	2932.0	1.0	29.5	245.5	553.5	2598.0
Bowdeniella nasicola_nov_81.4% (SPN31)	1.0	1.0	1.0	1.0	192.0	1.0	1.0	1.0	1.0	292.0
Clostridium diolis_nov_84.18% (SPN320)	1.0	1.0	1.0	88.75	253.0	1.0	1.0	1.0	71.75	300.0
Kocuria indica_nov_89.33% (SPN328)	1.0	1.0	1.0	1.0	273.0	1.0	1.0	1.0	14.0	125.0
Streptococcus rifensis_nov_91.68% (SPN349)	1.0	1.0	111.5	431.5	6650.0	1.0	1.0	5.0	158.75	3296.0
Natronincola ferrireducens_nov_85.53% (SPN356)	1.0	1.0	1.0	44.75	223.0	1.0	1.0	1.0	63.25	154.0
Streptococcus rifensis_nov_90.59% (SPN362)	1.0	1.0	1.0	56.25	681.0	1.0	1.0	1.0	6.75	583.0
Streptococcus rifensis_nov_90.67% (SPN37)	1.0	1.0	1.0	67.5	1080.0	1.0	1.0	1.0	72.75	3046.0
Thermomonospora curvata_nov_84.68% (SPN38)	1.0	1.0	1.0	1.0	102.0	1.0	1.0	1.0	1.0	97.0
Isoptericola jiangsuensis_nov_88.29% (SPN389)	1.0	1.0	1.0	26.75	185.0	1.0	1.0	1.0	1.0	247.0
Arenibacter algicola_nov_84.87% (SPN397)	1.0	1.0	1.0	54.5	182.0	1.0	1.0	1.0	29.25	279.0
Cellulosilyticum lentocellum_nov_84.21% (SPN4)	1.0	1.0	1.0	1.0	215.0	1.0	1.0	1.0	1.0	196.0
Geosporobacter subterraneus_nov_84.49% (SPN405)	1.0	1.0	1.0	69.0	187.0	1.0	1.0	1.0	1.0	250.0
Tonsilliphilus suis_nov_84.02% (SPN42)	1.0	1.0	1.0	1.0	279.0	1.0	1.0	1.0	1.0	288.0
Streptococcus rifensis_nov_90.43% (SPN420)	1.0	1.0	1.0	1.0	517.0	1.0	1.0	1.0	1.0	1633.0
Streptococcus pyogenes_nov_85.12% (SPN443)	1.0	1.0	1.0	20.25	196.0	1.0	1.0	1.0	43.0	177.0
Devriesea agamarum_nov_86.9% (SPN449)	1.0	1.0	1.0	1.0	136.0	1.0	1.0	1.0	1.0	296.0
Clostridium acetobutylicum_nov_85.27% (SPN454)	1.0	1.0	1.0	1.0	261.0	1.0	1.0	1.0	1.0	88.0
Oceanobacillus senegalensis_nov_85.28% (SPN458)	1.0	1.0	1.0	72.5	334.0	1.0	1.0	1.0	1.0	183.0
Anaerovibrio lipolyticus_nov_84.95% (SPN471)	1.0	1.0	1.0	1.0	423.0	1.0	1.0	1.0	1.0	176.0
Sneathia sanguinegens_nov_85.05% (SPN483)	1.0	1.0	60.0	235.0	1585.0	1.0	1.0	1.0	121.0	889.0
Lacticaseibacillus porcinae_nov_86.26% (SPN484)	1.0	1.0	1.0	1.0	293.0	1.0	1.0	1.0	1.0	204.0
Fusobacterium nucleatum_nov_86.73% (SPN504)	1.0	1.0	1.0	14.25	662.0	1.0	1.0	1.0	1.0	1645.0
Streptosporangium subfuscum_nov_84.24% (SPN510)	1.0	1.0	1.0	1.0	798.0	1.0	1.0	1.0	1.0	192.0
Bowdeniella nasicola_nov_87.61% (SPN515)	1.0	1.0	1.0	1.0	481.0	1.0	1.0	1.0	1.0	80.0
Leptotrichia sp. HMT498 nov_84.5% (SPN52)	1.0	1.0	1.0	1.0	161.0	1.0	1.0	1.0	1.0	106.0
Anaerovibrio lipolyticus_nov_85.06% (SPN530)	1.0	1.0	1.0	8.0	243.0	1.0	1.0	1.0	1.0	228.0
Streptococcus suis_nov_88.37% (SPN531)	1.0	1.0	1.0	1.0	248.0	1.0	1.0	1.0	1.0	294.0
Marinoscillum pacificum_nov_80.04% (SPN536)	1.0	1.0	1.0	56.25	212.0	1.0	1.0	1.0	3.25	134.0
Kocuria indica_nov_89.81% (SPN541)	1.0	1.0	1.0	142.25	2638.0	1.0	1.0	1.0	1.0	422.0
Peptostreptococcus anaerobius_nov_95.34% (SPN544)	1.0	1.0	1.0	87.5	209.0	1.0	1.0	1.0	3.5	153.0
Natronincola ferrireducens_nov_83.89% (SPN551)	1.0	1.0	1.0	45.75	173.0	1.0	1.0	1.0	1.0	76.0
Thermomonospora curvata_nov_84.47% (SPN565)	1.0	1.0	1.0	1.0	358.0	1.0	1.0	1.0	1.0	192.0
Actinomyces slackii_nov_90.12% (SPN571)	1.0	1.0	1.0	1.0	339.0	1.0	1.0	1.0	1.0	212.0
Thermincola potens_nov_80.71% (SPN578)	1.0	1.0	1.0	8.0	123.0	1.0	1.0	1.0	1.0	153.0
Alkaliphilus peptidifermentans_nov_82.53% (SPN585)	1.0	1.0	1.0	1.0	99.0	1.0	1.0	1.0	1.0	154.0
Actinomyces israelii_nov_96.89% (SPN586)	1.0	1.0	1.0	1.0	565.0	1.0	1.0	1.0	1.0	83.0
Isoptericola cucumis_nov_86.73% (SPN600)	1.0	1.0	1.0	1.0	1117.0	1.0	1.0	1.0	1.0	256.0
Clostridium acetobutylicum_nov_85.65% (SPN613)	1.0	36.25	91.0	232.75	1142.0	1.0	1.0	26.0	101.5	668.0
Cellulosimicrobium arenosum_nov_91.54% (SPN614)	1.0	1.0	1.0	46.25	191.0	1.0	1.0	1.0	1.0	190.0
Sneathia sanguinegens_nov_85.47% (SPN62)	1.0	1.0	1.0	20.75	147.0	1.0	1.0	1.0	1.0	65.0
Campylobacter rectus_nov_94.88% (SPN630)	1.0	1.0	1.0	18.5	203.0	1.0	1.0	1.0	1.0	217.0
Alkaliphilus peptidifermentans_nov_87.82% (SPN635)	1.0	1.0	1.0	1.0	138.0	1.0	1.0	1.0	1.0	138.0
Anaerovibrio lipolyticus_nov_85.17% (SPN64)	1.0	1.0	1.0	1.0	189.0	1.0	1.0	1.0	1.0	180.0
Chryseobacterium taeanense_nov_85.77% (SPN645)	1.0	1.0	1.0	47.5	152.0	1.0	1.0	1.0	12.25	100.0
Corynebacterium terpenotabidum_nov_92.36% (SPN66)	1.0	1.0	1.0	1.0	717.0	1.0	1.0	1.0	1.0	217.0
Flavobacterium subsaxonicum_nov_81.99% (SPN662)	1.0	1.0	1.0	1.0	76.0	1.0	1.0	1.0	1.0	105.0
Arenibacter algicola_nov_87.21% (SPN667)	1.0	1.0	1.0	43.25	297.0	1.0	1.0	1.0	1.0	119.0
Campylobacter rectus_nov_94.49% (SPN676)	1.0	1.0	1.0	50.75	135.0	1.0	1.0	1.0	33.5	158.0
Corynebacterium terpenotabidum_nov_93.1% (SPN682)	1.0	1.0	1.0	1.0	645.0	1.0	1.0	1.0	1.0	412.0
Corynebacterium terpenotabidum_nov_92.32% (SPN689)	1.0	1.0	14.0	143.75	1034.0	1.0	1.0	21.5	97.5	1619.0
Bowdeniella nasicola_nov_87.76% (SPN690)	1.0	1.0	1.0	1.0	142.0	1.0	1.0	1.0	1.0	120.0
Bhargavaea cecembensis_nov_82.42% (SPN700)	1.0	1.0	1.0	43.5	158.0	1.0	1.0	1.0	1.0	116.0
Dermacoccus sp._str._Ellin185_nov_89.57% (SPN710)	1.0	1.0	1.0	5.0	155.0	1.0	1.0	1.0	1.0	139.0
Alistipes indistinctus_nov_86.39% (SPN721)	1.0	1.0	1.0	1.0	210.0	1.0	1.0	1.0	1.0	503.0
Anaerovibrio lipolyticus_nov_86.86% (SPN729)	1.0	1.0	1.0	1.0	135.0	1.0	1.0	1.0	1.0	172.0
Streptococcus pyogenes_nov_90.1% (SPN736)	1.0	1.0	1.0	1.0	228.0	1.0	1.0	1.0	1.0	379.0
Alkaliphilus peptidifermentans_nov_86.76% (SPN750)	1.0	1.0	1.0	36.75	134.0	1.0	1.0	1.0	1.0	204.0
Alistipes indistinctus_nov_85.71% (SPN76)	1.0	1.0	1.0	1.0	144.0	1.0	1.0	1.0	1.0	111.0
Fusobacterium sp. HMT248 nov_86.16% (SPN770)	1.0	1.0	1.0	1.0	150.0	1.0	1.0	1.0	1.0	364.0
Selenomonas dianae_nov_87.22% (SPN779)	1.0	1.0	1.0	1.0	171.0	1.0	1.0	1.0	1.0	161.0
Geosporobacter subterraneus_nov_86.78% (SPN90)	1.0	1.0	1.0	1.0	176.0	1.0	1.0	1.0	1.0	94.0
Gramella marina_nov_84.87% (SPN93)	1.0	1.0	1.0	1.0	167.0	1.0	1.0	1.0	1.0	139.0
Cellulomonas gilvus_nov_87.87% (SPN96)	1.0	1.0	1.0	57.0	549.0	1.0	1.0	1.0	53.5	780.0
Streptococcus multispecies_spp14_2 (SPP14)	1.0	1.0	1.0	1.0	275.0	1.0	1.0	1.0	1.0	656.0
multigenus multispecies_sppn1_2_nov_97.18% (SPPN1)	1.0	1.0	1.0	1.0	154.0	1.0	1.0	1.0	1.0	271.0
Mycobacterium multispecies_sppn9_2_nov_83.57% (SPPN9)	1.0	1.0	1.0	717.75	8657.0	1.0	1.0	1.0	200.0	3050.0