Percentile	0.0	25.0	50.0	75.0	100.0	0.0	25.0	50.0	75.0	100.0
Group	Control_plate	Control_plate	Control_plate	Control_plate	Control_plate	Doxycycline	Doxycycline	Doxycycline	Doxycycline	Doxycycline
Fusobacterium nucleatum_subsp._animalis (SP1)	15.0	67.0	127.0	1820.0	4058.0	1.0	1.0	1.0	1.0	2.0
Bacteroidaceae_[G-1] sp._oral_taxon_272 (SP10)	2.0	2.0	4.0	6.0	73.0	1.0	1.0	1.0	1.0	1.0
Stomatobaculum sp._oral_taxon_373 (SP105)	1.0	1.0	1.0	3.0	9.0	1.0	1.0	1.0	1.0	1.0
Peptostreptococcaceae_[XI][G-7] [Eubacterium]_yurii_subsp._yurii_&_margaretiae (SP11)	1.0	5.0	29.0	266.0	739.0	1.0	1.0	1.0	1.0	1.0
Stomatobaculum sp._oral_taxon_097 (SP112)	1.0	5.0	14.0	18.0	257.0	1.0	1.0	1.0	2.0	9.0
Peptostreptococcaceae_[XI][G-7] sp._oral_taxon_081 (SP113)	1.0	1.0	1.0	1.0	7.0	1.0	1.0	1.0	1.0	1.0
Selenomonas dianae (SP114)	2.0	3.0	6.0	14.0	98.0	1.0	1.0	1.0	1.0	1.0
Oribacterium asaccharolyticum (SP115)	1.0	1.0	3.0	4.0	14.0	1.0	1.0	1.0	6.0	9.0
Parvimonas micra (SP12)	111.0	134.0	134.0	294.0	575.0	1.0	1.0	1.0	1.0	12.0
Actinomyces sp._oral_taxon_169 (SP121)	1.0	1.0	2.0	6.0	6.0	1.0	1.0	1.0	1.0	1.0
Rothia aeria (SP122)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Gemella morbillorum (SP125)	1.0	1.0	2.0	5.0	6.0	1.0	1.0	1.0	1.0	1.0
Fusobacterium nucleatum_subsp._nucleatum (SP126)	1.0	1.0	13.0	18.0	37.0	1.0	1.0	1.0	1.0	1.0
Fusobacterium periodonticum (SP129)	1.0	2.0	2.0	13.0	27.0	1.0	1.0	1.0	1.0	1.0
Eikenella corrodens (SP13)	35.0	59.0	86.0	257.0	400.0	1.0	1.0	1.0	3.0	5.0
Actinomyces meyeri (SP132)	1.0	1.0	1.0	1.0	81.0	1.0	1.0	1.0	1.0	1.0
Bacteroidales_[G-2] sp._oral_taxon_274 (SP133)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Parvimonas sp._oral_taxon_393 (SP134)	1.0	1.0	1.0	5.0	5.0	1.0	1.0	1.0	1.0	1.0
Streptococcus gordonii (SP135)	1.0	1.0	5.0	7.0	19.0	1.0	1.0	1.0	1.0	39.0
Granulicatella adiacens (SP14)	6.0	64.0	118.0	152.0	185.0	1.0	1.0	1.0	5.0	91.0
Aggregatibacter sp._oral_taxon_513 (SP146)	1.0	1.0	1.0	1.0	50.0	1.0	1.0	1.0	1.0	1.0
Actinomyces sp._oral_taxon_180 (SP147)	1.0	2.0	10.0	34.0	153.0	1.0	1.0	1.0	1.0	1.0
Leptotrichia wadei (SP15)	1.0	2.0	2.0	4.0	4.0	1.0	1.0	1.0	1.0	1.0
Atopobium sp._oral_taxon_199 (SP150)	1.0	1.0	1.0	3.0	9.0	1.0	1.0	1.0	1.0	1.0
Campylobacter rectus (SP153)	1.0	1.0	1.0	10.0	20.0	1.0	1.0	1.0	1.0	1.0
Prevotella saccharolytica (SP157)	1.0	2.0	3.0	4.0	19.0	1.0	1.0	1.0	1.0	1.0
Atopobium parvulum (SP158)	4.0	9.0	9.0	26.0	28.0	1.0	1.0	1.0	1.0	1.0
Abiotrophia defectiva (SP159)	1.0	1.0	3.0	3.0	5.0	1.0	1.0	1.0	1.0	135.0
Treponema denticola (SP16)	1.0	1.0	2.0	2.0	2.0	1.0	1.0	1.0	1.0	1.0
Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brachy (SP160)	1.0	1.0	3.0	8.0	16.0	1.0	1.0	1.0	1.0	1.0
TM7_[G-1] sp._oral_taxon_952 (SP161)	1.0	1.0	1.0	3.0	13.0	1.0	1.0	1.0	1.0	1.0
Lachnoanaerobaculum saburreum (SP167)	2.0	3.0	6.0	10.0	13.0	1.0	1.0	1.0	3.0	33.0
Streptococcus dentisani (SP17)	1.0	1.0	4.0	92.0	123.0	1.0	1.0	1.0	1.0	1.0
Selenomonas sp._oral_taxon_919 (SP170)	1.0	1.0	2.0	3.0	17.0	1.0	1.0	1.0	1.0	7.0
Capnocytophaga sp._oral_taxon_412 (SP173)	1.0	1.0	1.0	1.0	5.0	1.0	1.0	1.0	1.0	2.0
Acidaminococcus sp._str._D21 (SP175)	1.0	1.0	1.0	1.0	26.0	1.0	1.0	1.0	1.0	23.0
Peptostreptococcaceae_[XI][G-2] sp._oral_taxon_091 (SP176)	1.0	1.0	1.0	1.0	5.0	1.0	1.0	1.0	1.0	1.0
Streptococcus sp._str._C300 (SP178)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	41.0
Streptococcus parasanguinis_I (SP179)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	5.0
Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infirmum (SP18)	1.0	1.0	2.0	4.0	4.0	1.0	1.0	1.0	1.0	441.0
Dialister invisus (SP181)	1.0	1.0	3.0	5.0	9.0	1.0	1.0	1.0	1.0	1.0
Eikenella sp._oral_taxon_011 (SP182)	1.0	1.0	1.0	1.0	7.0	1.0	1.0	1.0	1.0	1.0
Lachnoanaerobaculum umeaense (SP183)	1.0	2.0	3.0	11.0	19.0	1.0	1.0	1.0	1.0	12.0
Pyramidobacter piscolens (SP185)	1.0	1.0	2.0	2.0	27.0	1.0	1.0	1.0	1.0	1.0
Actinomyces timonensis (SP189)	1.0	1.0	1.0	1.0	8.0	1.0	1.0	1.0	1.0	1.0
Staphylococcus epidermidis (SP19)	1.0	1.0	1.0	1.0	254.0	1.0	1.0	1.0	1.0	30.0
Oribacterium sinus (SP190)	7.0	7.0	14.0	19.0	46.0	1.0	1.0	2.0	3.0	19.0
Lachnospiraceae_[G-8] sp._oral_taxon_500 (SP191)	1.0	1.0	1.0	5.0	6.0	1.0	1.0	1.0	1.0	1.0
Streptococcus parasanguinis_II (SP2)	1.0	1.0	2.0	4.0	5.0	1.0	1.0	1.0	2.0	15066.0
Capnocytophaga gingivalis (SP20)	1.0	1.0	2.0	5.0	12.0	1.0	1.0	1.0	1.0	2.0
Megasphaera micronuciformis (SP203)	1.0	1.0	1.0	6.0	20.0	1.0	1.0	1.0	2.0	33.0
Actinomyces sp._oral_taxon_172 (SP204)	1.0	1.0	1.0	1.0	5.0	1.0	1.0	1.0	1.0	1.0
Selenomonas infelix (SP209)	1.0	1.0	2.0	3.0	32.0	1.0	1.0	1.0	1.0	3.0
Streptococcus sp._oral_taxon_423 (SP21)	7.0	13.0	19.0	51.0	88.0	1.0	1.0	1.0	153.0	1645.0
Actinomyces lingnae_[NVP] (SP210)	1.0	1.0	1.0	1.0	3.0	1.0	1.0	1.0	1.0	129.0
Leptotrichia sp._oral_taxon_392 (SP212)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Bifidobacterium dentium (SP216)	1.0	1.0	1.0	1.0	8.0	1.0	1.0	1.0	1.0	1.0
Streptococcus intermedius (SP217)	1.0	1.0	1.0	1.0	4.0	1.0	1.0	1.0	1.0	4.0
Selenomonas sp._oral_taxon_134 (SP219)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	70.0
Atopobium rimae (SP22)	4.0	4.0	7.0	7.0	34.0	1.0	1.0	1.0	1.0	37.0
Tannerella sp._oral_taxon_808 (SP221)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Actinomyces naeslundii (SP223)	1.0	1.0	1.0	2.0	2.0	1.0	1.0	1.0	1.0	1.0
Selenomonas sp._oral_taxon_388 (SP226)	1.0	1.0	1.0	1.0	56.0	1.0	1.0	1.0	1.0	1.0
Capnocytophaga sputigena (SP236)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	3.0
Selenomonas sp._oral_taxon_481 (SP238)	1.0	1.0	1.0	1.0	17.0	1.0	1.0	1.0	1.0	1.0
Streptococcus tigurinus (SP24)	2.0	2.0	110.0	305.0	332.0	1.0	1.0	1.0	1.0	24.0
Porphyromonas gingivalis (SP246)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Atopobium sp._oral_taxon_810 (SP255)	1.0	1.0	1.0	1.0	3.0	1.0	1.0	1.0	1.0	1.0
Aggregatibacter sp._oral_taxon_458 (SP256)	1.0	1.0	1.0	1.0	3.0	1.0	1.0	1.0	1.0	1.0
Porphyromonas endodontalis (SP26)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Campylobacter sp._Oral_Taxon_G43 (SP262)	1.0	1.0	1.0	3.0	50.0	1.0	1.0	1.0	1.0	1.0
Selenomonas sp._oral_taxon_149 (SP265)	1.0	1.0	1.0	1.0	4.0	1.0	1.0	10.0	15.0	30.0
Catonella morbi (SP268)	1.0	1.0	1.0	2.0	2.0	1.0	1.0	1.0	1.0	1.0
Streptococcus sp._oral_taxon_070 (SP27)	1.0	11.0	14.0	40.0	79.0	1.0	1.0	1.0	1.0	2.0
Pseudoramibacter alactolyticus (SP276)	1.0	1.0	1.0	2.0	2.0	1.0	1.0	1.0	1.0	1.0
Neisseria flavescens|subflava (SP29)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	2.0	2923.0
Fretibacterium fastidiosum (SP3)	1.0	1.0	1.0	1.0	4.0	1.0	1.0	1.0	1.0	1.0
Fusobacterium nucleatum_subsp._polymorphum (SP30)	32.0	155.0	231.0	313.0	818.0	1.0	1.0	1.0	1.0	1.0
Prevotella oralis (SP304)	1.0	1.0	1.0	2.0	16.0	1.0	1.0	1.0	1.0	1.0
Bilophila wadsworthia (SP308)	1.0	1.0	1.0	1.0	28.0	1.0	1.0	1.0	1.0	1.0
Olsenella uli (SP309)	2.0	2.0	5.0	9.0	10.0	1.0	1.0	1.0	1.0	4.0
Porphyromonas sp._oral_taxon_275 (SP32)	1.0	1.0	1.0	1.0	78.0	1.0	1.0	1.0	1.0	1.0
Veillonellaceae_[G-1] sp._oral_taxon_129 (SP323)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Fusobacterium nucleatum_subsp._vincentii (SP33)	2.0	30.0	76.0	277.0	366.0	1.0	1.0	1.0	1.0	2.0
Rothia dentocariosa (SP34)	1.0	1.0	1.0	1.0	46.0	1.0	1.0	1.0	1.0	3.0
Fusobacterium sp._oral_taxon_203 (SP35)	1.0	2.0	2.0	5.0	33.0	1.0	1.0	1.0	1.0	1.0
Anaeroglobus geminatus (SP354)	1.0	1.0	4.0	8.0	16.0	1.0	1.0	1.0	1.0	1.0
Streptococcus sp._oral_taxon_058 (SP36)	1.0	1.0	7.0	15.0	32.0	1.0	1.0	1.0	4.0	112.0
Fretibacterium sp._oral_taxon_360 (SP37)	1.0	1.0	1.0	1.0	7.0	1.0	1.0	1.0	1.0	2.0
Streptococcus sinensis (SP38)	1.0	1.0	1.0	1.0	101.0	1.0	1.0	1.0	1.0	1.0
Haemophilus parainfluenzae (SP39)	4.0	27.0	62.0	158.0	353.0	1.0	1.0	1.0	1.0	40.0
Rothia mucilaginosa (SP4)	1.0	1.0	3.0	9.0	704.0	1.0	1.0	2.0	2.0	1922.0
Leptotrichia buccalis (SP40)	1.0	1.0	1.0	2.0	4.0	1.0	1.0	1.0	1.0	1.0
Campylobacter showae (SP41)	1.0	4.0	41.0	198.0	404.0	1.0	1.0	1.0	1.0	1.0
Porphyromonas sp._oral_taxon_277 (SP415)	1.0	1.0	1.0	1.0	34.0	1.0	1.0	1.0	1.0	1.0
Streptococcus cristatus (SP42)	2.0	18.0	24.0	64.0	86.0	1.0	1.0	1.0	1.0	182.0
Streptococcus vestibularis (SP43)	1.0	1.0	1.0	1.0	9.0	1.0	1.0	1.0	1.0	1.0
Streptococcus salivarius (SP44)	1.0	1.0	1.0	2.0	98.0	1.0	1.0	1.0	1.0	1.0
Campylobacter gracilis (SP45)	6.0	15.0	37.0	79.0	86.0	1.0	1.0	1.0	1.0	2.0
Oribacterium sp._oral_taxon_078 (SP46)	1.0	10.0	18.0	58.0	93.0	1.0	1.0	1.0	3.0	28.0
Campylobacter concisus (SP47)	11.0	37.0	53.0	181.0	183.0	1.0	1.0	1.0	1.0	1.0
Mogibacterium timidum (SP49)	4.0	4.0	10.0	32.0	47.0	1.0	1.0	1.0	1.0	65.0
Streptococcus anginosus (SP5)	15.0	60.0	63.0	73.0	410.0	1.0	4.0	9.0	9141.0	14820.0
Veillonella atypica (SP52)	1.0	5.0	60.0	182.0	728.0	1.0	1.0	1.0	10.0	72.0
Streptococcus mitis (SP53)	1.0	1.0	4.0	5.0	5.0	1.0	1.0	1.0	1.0	151.0
Fusobacterium sp._oral_taxon_370 (SP56)	1.0	1.0	5.0	32.0	75.0	1.0	1.0	1.0	1.0	1.0
Streptococcus constellatus (SP57)	21.0	98.0	132.0	183.0	893.0	1.0	4.0	32.0	707.0	2671.0
Fusobacterium canifelinum (SP58)	1.0	1.0	2.0	7.0	31.0	1.0	1.0	1.0	1.0	1.0
Mogibacterium diversum (SP6)	2.0	30.0	32.0	35.0	38.0	1.0	1.0	1.0	1.0	1.0
Streptococcus sanguinis (SP60)	2.0	3.0	4.0	8.0	24.0	1.0	4.0	44.0	44.0	52.0
Veillonella sp._oral_taxon_780 (SP61)	1.0	1.0	1.0	2.0	51.0	1.0	1.0	1.0	1.0	1.0
Streptococcus oralis (SP62)	1.0	1.0	2.0	2.0	4.0	1.0	1.0	1.0	29.0	128.0
Streptococcus sp._Oral_Taxon_B66 (SP63)	1.0	1.0	1.0	3.0	4.0	1.0	1.0	1.0	1.0	117.0
Porphyromonas sp._oral_taxon_279 (SP65)	1.0	1.0	1.0	2.0	2.0	1.0	1.0	1.0	1.0	1.0
Stomatobaculum longum (SP66)	2.0	31.0	127.0	154.0	943.0	1.0	1.0	1.0	19.0	47.0
Prevotella oris (SP67)	1.0	1.0	1.0	1.0	3.0	1.0	1.0	1.0	1.0	1.0
Fusobacterium sp._HOT_204 (SP68)	1.0	1.0	1.0	5.0	41.0	1.0	1.0	1.0	1.0	1.0
Slackia exigua (SP69)	6.0	10.0	15.0	19.0	95.0	1.0	1.0	1.0	1.0	53.0
Veillonella parvula_group (SP7)	1114.0	1942.0	2133.0	2812.0	4123.0	1.0	2.0	367.0	1031.0	3125.0
Leptotrichia sp._oral_taxon_498 (SP70)	1.0	1.0	2.0	4.0	4.0	1.0	1.0	1.0	1.0	1.0
Dialister pneumosintes (SP73)	4.0	7.0	19.0	21.0	22.0	1.0	1.0	1.0	1.0	1.0
Eggerthia catenaformis (SP75)	1.0	1.0	1.0	1.0	4.0	1.0	1.0	1.0	1.0	4.0
Prevotella sp._oral_taxon_304 (SP76)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Streptococcus sp._oral_taxon_064 (SP78)	1.0	2.0	4.0	27.0	28.0	1.0	1.0	2.0	3.0	4.0
Leptotrichia sp._oral_taxon_215 (SP79)	2.0	2.0	2.0	3.0	8.0	1.0	1.0	1.0	1.0	125.0
Peptostreptococcus stomatis (SP8)	1.0	27.0	44.0	220.0	2527.0	1.0	1.0	1.0	1.0	90.0
Prevotella maculosa (SP80)	1.0	1.0	2.0	6.0	16.0	1.0	1.0	24.0	381.0	552.0
Bacteroides heparinolyticus (SP81)	1.0	1.0	1.0	1.0	69.0	1.0	1.0	1.0	1.0	1.0
Actinomyces odontolyticus (SP83)	2.0	4.0	8.0	30.0	47.0	1.0	1.0	1.0	1.0	1.0
Prevotella salivae (SP85)	1.0	1.0	1.0	2.0	3.0	1.0	1.0	1.0	1.0	1.0
Selenomonas sputigena (SP86)	1.0	1.0	3.0	9.0	20.0	1.0	1.0	1.0	2.0	105.0
Tannerella forsythia (SP87)	1.0	1.0	1.0	1.0	19.0	1.0	1.0	1.0	1.0	1.0
Solobacterium moorei (SP88)	2.0	4.0	8.0	14.0	19.0	1.0	1.0	1.0	22.0	42.0
Prevotella denticola (SP89)	1.0	1.0	1.0	2.0	9.0	1.0	1.0	1.0	1.0	2.0
Leptotrichia sp._oral_taxon_417 (SP9)	1.0	1.0	1.0	2.0	4.0	1.0	1.0	1.0	1.0	1.0
Prevotella sp._oral_taxon_317 (SP91)	1.0	1.0	1.0	6.0	16.0	1.0	1.0	1.0	1.0	1.0
Streptococcus sp._oral_taxon_056 (SP96)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	20.0
Streptococcus mutans (SP99)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	333.0
Capnocytophaga gingivalis_nov_97.912% (SPN106)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Actinomyces naeslundii_nov_97.980% (SPN123)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Streptococcus oralis_nov_97.992% (SPN134)	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	33.0
Fusobacterium sp._oral_taxon_370_nov_97.650% (SPN25)	1.0	1.0	1.0	1.0	17.0	1.0	1.0	1.0	1.0	1.0
Laceyella sediminis_nov_84.583% (SPN37)	1.0	1.0	1.0	1.0	3.0	1.0	1.0	1.0	1.0	1.0
Actinomyces meyeri_nov_87.247% (SPN82)	1.0	1.0	1.0	1.0	2.0	1.0	1.0	1.0	1.0	1.0
Clostridiales_[G] sp._Oral_Taxon_C16_nov_79.093% (SPN93)	1.0	2.0	2.0	2.0	29.0	1.0	1.0	1.0	1.0	3.0
Fusobacterium multispecies_spp11_2 (SPP11)	1.0	1.0	1.0	2.0	18.0	1.0	1.0	1.0	1.0	1.0
Streptococcus multispecies_spp12_2 (SPP12)	1.0	3.0	3.0	4.0	7.0	1.0	1.0	1.0	1.0	1.0
Oribacterium multispecies_spp3_2 (SPP3)	1.0	2.0	2.0	5.0	6.0	1.0	1.0	1.0	2.0	10.0
Veillonella multispecies_spp4_2 (SPP4)	1.0	2.0	2.0	5.0	21.0	1.0	1.0	1.0	42.0	107.0